Integrating New Antiretroviral Agents Into Therapeutic Strategies for Treatment-Experienced Patients

Newly Available!

CCO HIV Stay Tuned

Bimonthly CME-certified audio Podcasts, each supported by a variety of online resources.

Evolving Concepts in Antiretroviral Therapy—Volume 1, Edition 1 Watch and listen to CCO's expert faculty discuss evolving concepts in antiretroviral therapy. Then download audio, video, and slides for additional reference and use in your own talks. Click here to start.

Also Available!

Evolving Concepts in Antiretroviral Therapy—Volume 1, Edition 2

Watch and listen to CCO's expert faculty discuss additional evolving concepts in antiretroviral therapy. Then download audio, video, and slides for additional reference and use in your own talks.  Click here to start.

HIV/AIDS Annual Update 2008

Clinical Care Options' HIV/AIDS Annual Update offers the latest information across a wide range of issues for the optimal clinical management of your patients. Expert faculty members prepared the following CME-certified educational modules that are now available on the CCO Web site:

CME-Certified Modules:

The Role of Integrase Inhibitors in HIV Management

2 CME-Certified modules by Martin Markowitz, MD:

• Targeting Integrase: Mechanisms of Action and Mechanisms of Resistance to Integrase Inhibitors
  Martin Markowitz, MD, discusses the role of the integrase enzyme in the HIV replication cycle and the development of resistance to integrase inhibitors.
  
• Clinical Studies of Integrase Inhibitors: A Comprehensive Review
  Martin Markowitz, MD, discusses recent data from clinical studies involving the use of the integrase inhibitors raltegravir and elvitegravir.

CME-Certified module by David A. Cooper, MD, DSc:

• From Bench to Bedside: The Clinical Role of Integrase Inhibitors
  David A. Cooper, MD, DSc, discusses clinical data on the use of integrase inhibitors for the management of treatment-experienced and treatment-naive HIV-infected patients.

Interactive Case Challenges:

• Management of a Virologically Suppressed Patient Experiencing Injection-Site Reactions With His Current Regimen
  Jonathan M. Schapiro, MD, discusses management issues in the case of a treatment-experienced male who is experiencing intolerable adverse effects from his successful regimen.
  
• Management of a Patient With Extensive Antiretroviral Experience and Persistent Low-Level Viremia
  Edwin DeJesus, MD, FACP, discusses issues in managing a clinically stable male patient who has not been able to achieve undetectable HIV-1 RNA.

CCO Slideset:

• The Role of Integrase Inhibitors in HIV Management
  Martin Markowitz, MD, presents findings on the function of integrase and the role of integrase inhibitors in the management of HIV disease.
  

Evolving Insights Into the Optimal Timing of Antiretroviral Therapy

Now Available!

CME-certified Virtual Presentation:

Evolving Insights Into the Optimal Timing of Antiretroviral Therapy Paul E. Sax, MD, discusses the latest data regarding when to start antiretroviral therapy.

CME-certified Slideset:

Evolving Insights Into the Optimal Timing of Antiretroviral Therapy Paul E. Sax, MD, reviews the optimal timing of antiretroviral therapy in response to revised recommendations issued by the Department of Health and Human Services.

CCO Independent Conference Coverage of the 2008 Conference on Retroviruses and Opportunistic Infections

CME-Certified Expert Analyses:

• First-Line Therapy and Switch Strategies
• Management of Treatment-Experienced Patients
• Antiretroviral Drug Resistance
• Metabolic Complications and Adverse Events
• Hepatitis and Opportunistic Coinfections
  

CME-Certified Expert Recaps:

• First-Line Therapy and Switch Strategies
• Management of Treatment-Experienced Patients

And downloadable PowerPoint slides for review or to use in your own talks!

Answering the Questions: Practical Management Strategies to Address Cardiovascular Risk in HIV

CME-Certified Modules:

CCO Slideset:

Answering the Questions: Practical Management Strategies for Cardiovascular Risk in HIV Pablo Tebas, MD reviews key data on frequently asked questions about diagnosing and managing cardiovascular risks in HIV-infected patients.

HIV Journal Options - Volume 4, Issue 1

HIV Journal Options - Volume 4, Issue 2

HIV Journal Options - Volume 4, Issue 3 - Now Available!

New Topics include:

• Fibrosis Progression for HCV/HIV-Coinfected Patients
• Single-Agent PI Therapy
• HCV Superinfection
• Data Supporting an Earlier Start for Antiretrovirals
• Impact of HIV Suppression and Kidney Disease Stage on Renal Function
• Non-AIDS Cancers in an Aging HIV-Infected Population
• Benefits and Risks of HLA-B*5701 Screening for Abacavir Hypersensitivity
• Insights Into the Impact of Intermittent Viremia

Rethinking the Role of NNRTIs: Clinical Strategies for Optimizing Outcomes With Next-Generation Agents

CME-Certified Virtual Presentation and Downloadable PowerPoint Slideset:

• Rethinking the Role of NNRTIs: Clinical Strategies for Optimizing Outcomes With Next-Generation Agents
  Joseph J. Eron, Jr., MD, discusses clinical data and strategies important for optimal use of next-generation NNRTIs in the management of HIV-infected patients.
  
• CCO Slideset: Rethinking the Role of NNRTIs: Clinical Strategies for Optimizing Outcomes With Next-Generation Agents
  PowerPoint slideset available for review and use in your own educational presentations.

CME-Certified Case Vignettes:

• Clinical Management of a Patient Who Develops Additional Resistance Mutations When Maintained on a Failing Antiretroviral Regimen
  Joseph J. Eron, Jr., MD, discusses the management of an HIV-infected male who experiences treatment failure and subsequently develops multiple resistance mutations.
  
• Selecting an Antiretroviral Regimen in a Treatment-Experienced Patient Who has Never Achieved Undetectable Viral Load
  Pablo Tebas, MD, reviews considerations influencing management strategies in a patient with virologic failure and multidrug-resistant HIV.
  
• Using Recently Approved Antiretrovirals in the Management of a Highly Treatment-Experienced HIV-Infected Woman
  W. David Hardy, MD, discusses considerations when deciding which new antiretroviral agents to use in the clinical management of a highly treatment-experienced HIV-infected woman.

Psychiatric Disorders in HIV-Infected Patients

CME-certified Modules:

• Diagnosis and Treatment of Psychiatric Disorders in HIV-Infected Patients
  Stephen J. Ferrando, MD, outlines current understanding of psychiatric comorbidities in HIV-infected patients and treatment for each disorder.
  
  
• Impact of Psychiatric Disorders on HIV Management
  Ian Everall, FRCPath, FRCPsych, PhD, discusses the clinical management of HIV-infected individuals with mental illnesses such as major depressive disorder, anxiety disorders, psychotic disorders, and substance abuse.

CME-certified Interactive Case Challenges:

• Initiating Therapy in a Patient With Substance Abuse Disorder
  Andrew Angelino, MD, guides the participant through the decisions that might be faced when starting antiretroviral medications in a patient with a chaotic lifestyle and substance addiction.
  
  
• Managing Therapy in a Patient With Increasing Anxiety
  Stephen J. Ferrando, MD, describes management of a young HIV-infected woman with posttraumatic stress disorder.
  
  
• Managing Adherence in a Patient With Multiple Medical Disorders and an Affective Disorder
  Mary Alice O’Dowd, MD, guides the participant through a case involving a middle-aged patient with multiple medical disorders who must manage her antiretroviral medications, her other essential medications, and treatment for an affective disorder

Simple From the Start

2 CME-certified modules by Edwin DeJesus, MD, FACP:

• Recent Advances in Simplifying Antiretroviral Therapy
• Clinical Significance of Simplicity and Adherence in Antiretroviral Therapy
  
  

CME-certified Interactive Case Challenges:

• Selection of Initial Therapy for a 48-Year-Old HIV/TB-Coinfected Woman With CVD Risk Factors
• Management of a 38-Year-Old Male on Methadone Maintenance Therapy Who Presents With PCP
• Management of a 38-Year-Old Otherwise Healthy Married Man Recently Diagnosed With HIV Infection
  

The Clinical Impact of Next-Generation NNRTIs: Recent Research and Practical Treatment Strategies

A comprehensive review of data from clinical trials investigating first- and next-generation NNRTIs as well as a discussion regarding the clinical need for and potential impact of next-generation NNRTIs.

	Virtual Presentation The Clinical Need for Next-Generation NNRTIs
	Virtual Presentation The Potential Clinical Impact of Next-Generation NNRTIs
	A CME-certified Module: The Next Generation of NNRTIs

From Theory to Practice: Strategies for the Successful Management of Treatment-Experienced Patients

Interesting Interactive Case Challenges and Commentaries that explore treatment decisions for antiretroviral-experienced patients.

Interactive Case Challenges - Wave 1:

• Management of a Moderately Treatment-Experienced HIV-Infected Patient With Virologic Failure: Anton L. Pozniak, MD, FRCP
• Management of a Highly Treatment-Experienced HIV-Infected Patient With Low-Level Viremia and a High CD4+ Cell Count: Edwin DeJesus, MD, FACP

Interactive Case Challenges - Wave 2:

• Management of a Patient With Virologic Failure of an Initial PI-Based Regimen: W. David Hardy, MD
• Optimizing Therapy for a Highly Treatment-Experienced Patient With Viremia Currently on a Nonsuppressive Regimen: Joseph J. Eron, Jr., MD

Expert Commentaries:

• Practical Strategies for Managing Treatment-Experienced Patients: An Overview of the Wave 1 Interactive Case Challenges
• Practical Strategies for Managing Treatment-Experienced Patients: An Overview of the Wave 2 Interactive Case Challenges

• 2008 Conference on Retroviruses and Opportunisitic Infections *
  
  
• 2007 European AIDS Conference*
  
  
• 2007 Interscience Conference on Antimicrobial Agents and Chemotherapy *
  
  
• 2007 IAS Conference on HIV Pathogenesis, Treatment and Prevention
  
  
• 2007 International HIV Drug Resistance Workshop*
  
  
  
  

*CCO is an independent medical education company that provides state-of-the-art medical information to healthcare professionals through conference coverage and other educational programs.

• Managing Cardiovascular Risk in HIV-Infected Patients: The Role of Antiretroviral Selection
  Access 2 CME-certified  modules and a downloadable slideset.
  
  
• Right From the Start: Optimizing First-Line Antiretroviral Therapy
  Read educational modules from, Kimberly Y. Smith, MD, MPH, Edwin DeJesus, MD, FACP, Paul E. Sax, MD, and Valerie E. Stone, MD, MPH.
  
  
• HIV Entry and Tropism: New Strategies for Effective Antiretroviral Therapy
  Review educational modules and then download slides for your talks.
  
  
• New Classes of Antiretrovirals: The Potential Clinical Role of Integrase Inhibitors and Entry Inhibitors
  CME-certified modules on these exciting new classes of drugs for treatment-experienced patients.

• When to Start, What to Use: A Master Class in the Use of First-Line Antiretroviral Therapy
  Review 3 Modules, Interactive Case Challenges and an interactive tool.
  

• Selection of Initial Therapy for a 48-Year-Old HIV/TB-Coinfected Woman With CVD Risk Factors
  Anton L. Pozniak, MD, FRCP, discusses drug interaction and adherence issues in designing a therapy for a 48-year-old woman coinfected with HIV and tuberculosis.
  
  
• Management of a 38-Year-Old Male on Methadone Maintenance Therapy Who Presents With PCP
  William G. Powderly, MD, discusses the selection of initial therapy for a 38-year-old recovering injection drug user male with HIV/hepatitis C virus coinfection who presents with Pneumocystis jirovecii pneumonia (PCP).
  
  
• Management of a 38-Year-Old Otherwise Healthy Married Man Recently Diagnosed With HIV Infection
  Edwin DeJesus, MD, FACP, discusses key concerns about the initiation of antiretroviral therapy for a 38-year-old busy professional man recently diagnosed with HIV.
  
  
• Selection of an Initial Regimen for a Patient With a Family History of Cardiovascular Disease
  William G. Powderly, MD, challenges your knowledge of assessing cardiovascular risk for this patient as you select his initial regimen.
  
  
• Management of Dyslipidemia in an HIV-Infected Man With Grave Cardiac Risk
  Jens D. Lundgren, MD, DMSc, and Signe Westring Worm, MD, guide participants through the assessment of cardiac risk and treatment choices in a middle-aged patient with a high risk of a cardiovascular event.
  
  
  

Topics

• Adverse Effects and Comorbidities
• Antiretroviral Management
• Epidemiology and Natural History
• Opportunistic Diseases and Coinfection
• Pharmacology
• Resistance
• Special Populations

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FEATURED VIDEO SEGMENT
Case of the Month: Use of New Agents in a Patient With Limited Treatment Experience

Paul E. Sax, MD, guides you through the management of a moderately treatment-experienced patient with options limited by coadministered psychiatric medications. Click here to Start

Cardiac Abnormalities More Common in HIV-Infected Asymptomatic Adults vs HIV-Negative Controls

Prospective, observational study finds HIV infection associated with more cardiac abnormalities, such as diastolic dysfunction and increased left ventricular mass, than found in HIV-uninfected controls

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