Management of Depression and HCV: Novel Data, Best Practices, and Case Challenges

CME-Certified Modules:

Clinical Data and Best Practices for Managing Depression in HCV-Infected Patients Treated With Peginterferon and Ribavirin Martin Schaefer, MD, highlights management strategies for patients with hepatitis C virus infection and depression, highlighting new studies from the past year.

Answering the Questions: Depression Related to HCV and Its Treatment (Coming Soon)

CME-Certified Slideset Modules:

• Clinical Data and Best Practices for Managing Depression in HCV-Infected Patients Treated With Peginterferon and Ribavirin
  In this slideset module, Martin Schaefer, MD, discusses the relationships among depression, hepatitis C virus, and treatment; management strategies for depression; the effects of hepatitis C virus on cognitive function; and management of psychiatric disorders in the setting of drug addiction.
  
• Depression Related to HCV and Its Treatment (Coming Soon)

CME-Certified Interactive Case Challenges and accompanying Expert Viewpoints:

	Management of a 43 Year-Old HCV-Infected, Treatment-Naive Female With a History of Major Depression Join Charles L. Raison, MD, in choosing the optimal treatment strategies for a woman with recently diagnosed hepatitis C virus infection and a history of major depression.
	Expert Viewpoint by Patrick Marcellin, MD: Regional Perspectives on the Management of Depression Prior to HCV Therapy

	Management of a Patient Without a History of Depression Who Develops Psychiatric Complications During HCV Therapy Mark S. Sulkowski, MD, discusses factors to consider when psychiatric disorders develop in patients treated for chronic hepatitis C.
	Expert Viewpoint by Martin Schaefer, MD: Regional Perspectives on the Management of a Patient Without a History of Depression Who Develops Psychiatric Complications During HCV Therapy

	Management of Emergent Depression and Suicidal Ideation During HCV Therapy Join Alfredo Alberti, MD, in choosing the optimal treatment strategies for a woman who develops depressive symptoms during HCV therapy, despite the absence of symptoms at treatment baseline.
	Expert Viewpoint by Michael R. Kraus, MD, PhD: Regional Perspectives on the Management of Emergent Depression and Suicidal Ideation During HCV Therapy

Minimizing Barriers and Maximizing Response: Strategies and Tools for Frontline Providers Caring for Patients With Chronic Hepatitis C

Interesting Interactive Case Challenges and Virtual Presentations that explore treatment decisions for patients with chronic hepatitis C.

Now Available!

CME/CE-Certified Interactive Case Challenges:

• Management of a Patient With Hepatitis C Genotype 1 Infection Who Relapsed After a Course of Standard Interferon and Ribavirin
  Join Tiffany A. Geahigan, PA-C, CCRC, in choosing the optimal treatment strategies for an obese black patient with genotype 1 hepatitis C who relapsed after a course of standard-dose interferon alfa and ribavirin.
• Retreatment of a Patient Failing Previous HCV Therapy
  Anne Croghan, MN, ARNP, discusses treatment options and predictors of response for patients relapsing on previous peginterferon/ribavirin therapy.
• Management of an HCV-Infected Male With Advanced Liver Disease
  Gregory T. Everson, MD, FACP, discusses management strategies for a patient with advanced hepatitis C.

CME/CE-Certified Virtual Presentations:

Minimizing Barriers and Maximizing Response: Strategies and Tools for Frontline Providers Caring for Patients With Chronic Hepatitis C
Michael W. Fried, MD, discusses strategies to tailor hepatitis C virus treatment according to a patient’s individual response.

Downloadable PowerPoint slideset available for review and use in your own educational presentations.

Tailoring HCV Treatment to Patients With Advanced Liver Disease
Join Douglas M. Heuman, MD, FACP, as he discusses the impact of advanced fibrosis and cirrhosis on treatment approaches for HCV infection.

Downloadable PowerPoint slideset available for review and use in your own educational presentations.

Managing the Difficult-to-Treat HCV Patient
K. Rajender Reddy, MD, discusses considerations for the management of HCV-infected patients who are nonresponders or relapsers to previous HCV therapy.

Downloadable PowerPoint slideset available for review and use in your own educational presentations.

Also Available!

Interactive Decision Support Tools:

	HCV Drug Dose and Response
	Key Questions for Patients Facing HCV Retreatment

HBV Core Curriculum 2008

Now Available!

CME-Certified Virtual Presentation:

Downloadable Slideset:

CME-Certified Virtual Presentation:

Downloadable Slideset:

Downloadable Worksheets:

HBV Patient Monitoring Worksheets

These 4 convenient worksheets help streamline HBV screening and management decisions:

• Patient History/Initial Screen for HBV  
• Screening and Diagnosis Laboratory Results  
• Pretreatment Patient Monitoring  
• Patient Treatment Initiation

Coming Soon!

Interactive Decision Support Tool:

HBV Screening, Evaluation, and Monitoring
This tool guides HBV treaters through screening and baseline factors involved in making management decisions for their HBV-infected patients and emphasizes how information collected may affect management decisions.

HBV Election 2008: Meet the Clinical Candidates

• New Clinical Candidates for HBV
  Tram T. Tran, MD, and Robert S. Brown, Jr., MD, MPH, discuss new agents for the treatment of chronic hepatitis B and how they might fit in the treatment landscape.
  
  
• Downloadable Slideset
  Review the new therapies for hepatitis B and the clinical issues facing these candidates.

Hepatitis Annual Update 2008

Clinical Care Options' Hepatitis Annual Update offers the latest information across a wide range of hepatic issues for the optimal clinical management of your patients. Expert faculty members prepared the following CME-certified educational modules that are now available on the CCO Web site:

• Can Hepatitis B Be Cured?
• Therapy of Chronic Hepatitis B: Who to Treat and When to Treat? A Case-Based Discussion
• Therapy of Chronic Hepatitis B: What to Choose, When to Change, and When to Stop
• New Data on Currently Available Hepatitis C Therapies and Their Impact on Initial Treatment Strategies
• Strategies for Management of Hepatitis C Treatment Failure
• HCV Therapy: What Will the Future Look Like?
• Update on Autoimmune Hepatitis: Management Strategies
• Managing the Complications of Cirrhosis
• Hepatitis Journal Club: Top Clinical Articles of 2007-08

New Options for HCV Nonresponders: Navigating Emerging Data and Best Practices for Treatment-Experienced Patients

This Treatment Update is specifically designed for frontline providers, nurse practitioners, physician assistants, and others who treat patients who have been previously treated for HCV. It provides program participants with the latest data and best practices on management approaches for these patients as well as a means to synthesize these strategies through Interactive Case Challenges.

Part 1 - Management of Previous HCV Treatment Nonresponders

CME-Certified Virtual Presentation:
Management of HCV Nonresponders
Join Ira M. Jacobson, MD, as he discusses treatment strategies for the optimal management of patients with chronic hepatitis C with previous nonresponse to antiviral therapy.

Downloadable Slideset:
Management of HCV Nonresponders
Download and review key data selected by Ira M. Jacobson, MD, on the retreatment of patients with a previous nonresponse to HCV therapy. Use the slides for self-study and in your own presentations!

Interactive Case Challenge:
Treatment of a Genotype 1a Patient Not Achieving Full Virologic Suppression With Peginterferon/Ribavirin at 24 Weeks
Maria H. Sjogren, MD, MPH, FACP, discusses the treatment management options for patients not achieving HCV RNA suppression by 24 weeks of peginterferon alfa-2b/ribavirin treatment.

Part 2 - Optimizing and Individualizing HCV Retreatment

CME-Certified Virtual Presentation:
Maintaining Patients on Treatment: Optimizing and Individualizing Retreatment for Success
Join Bruce R. Bacon, MD, as he discusses strategies for maintaining therapy in patients who are being retreated for hepatitis C.

Downloadable Slideset:
Maintaining Patients on Treatment: Optimizing and Individualizing Retreatment for Success
Download and review key data selected by Bruce R. Bacon, MD, on optimizing and individualizing retreatment with available agents in patients with a previous suboptimal response to HCV therapy. Use the slides in your own presentations!

Interactive Case Challenge:
Optimizing Treatment Success of a Second HCV Regimen in a Patient With Unsuccessful Initial Treatment With Peginterferon alfa-2a and Ribavirin
Robert Gish, MD, discusses management strategies for a patient predisposed to anemia and depression.

CCO Independent Conference Coverage of the 43rd Annual Meeting of the European Association for the Study of the Liver

Expert Analyses:

• Update on Hepatitis B Management
  Kris V. Kowdley, MD, FACP, FACG, FASGE, AGAF; Patrick Marcellin, MD; Norah Terrault, MD, MPH
  
• Focus on Investigational HCV Agents
  Nezam H. Afdhal, MD, FRCPI; Ira M. Jacobson, MD; Stefan Zeuzem, MD
  
• New Advances in Hepatitis C
  Alfredo Alberti, MD; Peter Ferenci, MD; Michael P. Manns, MD
  
• Highlight on Special Hepatic Issues and Populations
  Robert G. Gish, MD; Josep M. Llovet, MD; Paul Martin, MD

Expert Recaps:

• Update on Hepatitis B Management  - Daniel Shouval, MD
• Focus on Investigational HCV Agents - Nezam H. Afdhal, MD, FRCPI

• Advanced Topics in Hepatitis C Management: Tools for Nurse Practitioners and Physician Assistants
  Review educational modules, case challenges and downloadable slides. An HCV RNA Monitoring Tool is also available.
  

• On-Treatment Management Strategies for Chronic Hepatitis B
  Along with Kris V. Kowdley, MD, FACP, FACG, FASGE, AGAF, choose management strategies for a patient with chronic hepatitis B receiving treatment with adefovir. Then, join Ira M. Jacobson, MD, as he reviews on-treatment hepatitis B virus guidelines including the relationships between early responses to oral anti-hepatitis B virus agents and future treatment outcomes.
  
  
• Virologic Tools for Monitoring Patients With Chronic Hepatitis B
  Use an interactive tool to tracks a patient’s progress on therapy by calculating and graphically representing changes in HBV DNA over time. The tool also generates key patient evaluation dates and interprets the patient progress over time by highlighting response patterns and tailoring responses according to treatment history. The tool has the capability to save patient data only on the end-user’s computer, making it available for editing upon subsequent uses.
  
  
• Drug Resistance in Chronic Hepatitis B: From Definitions to Management Strategies
  Access an educational module and Virtual Presentation from Emmet B. Keeffe, MD, MACP and Paul Martin, MD.
  
  
• New Management Strategies for HCV Nonresponders and Relapsers
  Join Tarek Hassanein, MD and Mitchell L. Shiffman, MD to review new data in an interactive case, downloadable slideset and an on-demand teleconference.
  
  
• Case Debates With the Experts: Applying the Updated Practice Guidelines to the Management of Hepatitis B
  Access three Interactive Case Challenges and three downloadable slidesets.
  

• 2008 Conference on Hepatitis B and C Virus Resistance to Antiviral Therapies
  
• 2008 Annual Meeting of the European Association for the Study of the Liver*
  
• 2007 Annual Meeting of the American Association for the Study of Liver Diseases*
  
  

*CCO is an independent medical education company that provides state-of-the-art medical information to healthcare professionals through conference coverage and other educational programs.

• On-Treatment Management of a Patient With Chronic Hepatitis B Receiving Adefovir Therapy
  
  
• Management of a Treatment-Naive, 54-Year-Old Woman Experiencing Anemia and Virologic Breakthrough During HCV Therapy

Topics

• Fibrosis and Cirrhosis
• HBV
• HCV
• Hepatocellular Carcinoma
• HIV Coinfection
• Nash, ALD, etc.
• Other Hepatitis Viruses
• Transplantation

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Interim Analysis: High Response Rates With Boceprevir Plus Standard of Care in Treatment-Naive Patients With Genotype 1 HCV Infection

Interim results of phase II HCV SPRINT-1 study in treatment-naive genotype 1 hepatitis C-infected patients demonstrate RVR an excellent predictor of SVR12 for the protease inhibitor boceprevir. More

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Join Charles L. Raison, MD, in choosing the optimal treatment strategies for a woman with recently diagnosed hepatitis C virus infection and a history of major depression.

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