CCO Interactive Case Challenges
From Theory to Practice: Strategies for the Successful Management of Treatment-Experienced Patients
Interactive Case Challenges - Wave 1
Management of a Moderately Treatment–Experienced HIV-Infected Patient With Virologic Failure
- Anton L. Pozniak, MD, FRCP
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 Along with Anton L. Pozniak, MD, FRCP, choose management strategies in a moderately treatment–experienced patient who is currently failing his antiretroviral regimen due to a difficulty adhering to therapy. Learning Objectives
Upon completion of this activity, participants should be able to:
- Describe the treatment goals of antiretroviral therapy for moderately antiretroviral-experienced patients
- Explain how best to utilize HIV resistance testing and treatment history to construct potent antiretroviral regimens
- Define antiretrovirals available for use in the management of moderately antiretroviral–experienced patients
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Management of a Highly Treatment-Experienced HIV-Infected Patient With Low-Level Viremia and a High CD4+ Cell Count
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Along with Edwin DeJesus, MD, FACP, choose management strategies in a highly treatment–experienced patient who is currently presenting with low-level viremia and a high CD4+ cell count Learning Objectives
Upon completion of this activity, participants should be able to:
- Describe the treatment goals of antiretroviral therapy for highly antiretroviral–experienced patients
- Explain how best to utilize HIV resistance testing in highly antiretroviral–experienced patients
- Define antiretrovirals available for use in the management of highly antiretroviral–experienced patients
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Practical Strategies for Managing Treatment-Experienced Patients: An Overview of the Wave 1 Interactive Case Challenges
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 Eric S. Daar, MD, reviews the management strategies of 2 treatment-experienced patients that were discussed as part of separate Interactive Case Challenges and comments on participant voting patterns. Learning Objectives
Upon completion of this activity, participants should be able to:
- Describe the treatment goals of antiretroviral therapy for treatment-experienced patients
- Explain how best to utilize HIV resistance testing in antiretroviral-experienced patients
- Define the antiretrovirals available for use in the management of treatment-experienced patients
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Interactive Case Challenges - Wave 2
Management of a Patient With Virologic Failure of an Initial PI-Based Regimen
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Along with W. David Hardy, MD, choose management strategies for a patient who has recently failed an initial PI-based regimen. Learning Objectives
Upon completion of this activity, participants should be able to:
- Recall the importance of resistance testing prior to initiation of antiretroviral therapy
- Explain the importance of resistance testing following virologic failure
- Describe how drug-drug interactions with proton-pump inhibitors may affect antiretroviral therapy
- Discuss the results of recent phase III clinical trials comparing PI-based regimens
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Optimizing Therapy for a Highly Treatment–Experienced Patient With Viremia Currently on a Nonsuppressive Regimen
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Along with Joseph J. Eron, Jr., MD, choose management strategies in a highly treatment–experienced patient presenting with low-level viremia and generally poor health who is currently receiving a nonsuppressive HAART regimen. Learning Objectives
Upon completion of this activity, participants should be able to:
- Describe the treatment goals of antiretroviral therapy for highly treatment–experienced patients
- Explain how best to utilize HIV resistance testing in highly treatment–experienced patients
- Define how to determine the optimal number of active agents to include in a regimen of a highly treatment–experienced patient with limited treatment options
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Practical Strategies for Managing Treatment-Experienced Patients: An Overview of the Wave 2 Interactive Case Challenges
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Eric S. Daar, MD, reviews the management strategies for 2 treatment-experienced patients as discussed in separate Interactive Case Challenges and comments on participant case voting patterns. Learning Objectives
Upon completion of this activity, participants should be able to:
- Describe how drug-drug interactions with proton pump inhibitors may affect antiretroviral therapy
- Discuss how best to determine antiretroviral susceptibility in treatment-experienced patients
- Define the FDA-approved antiretrovirals from novel classes that are available for the management of treatment-experienced patients
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Disclaimer: The materials published on the Clinical Care Options Web site reflect the views of the reviewers or authors of the CCO material, not those of Clinical Care Options, LLC, the CME provider, or the companies providing educational grants. The materials may discuss uses and dosages for therapeutic products that have not been approved by the United States Food and Drug Administration. A qualified healthcare professional should be consulted before using any therapeutic product discussed. Readers should verify all information and data before treating patients or using any therapies described in these materials.
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Jointly sponsored by Medical Education Collaborative and Clinical Care Options, LLC.
Educational grant provided by:
Educational grants support only the CME-certified components of this program.
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