Pharmacology and Adverse Drug Effects

Faculty:

Stephen L. Becker, MD Courtney V. Fletcher, PharmD Charles W. Flexner, MD

Learning Objectives

Upon completion of this activity, participants should be able to:

• Discuss potential drug-drug interactions between antiretroviral and nonantiretroviral drugs, and their clinical implications

• Recount new data on antiretroviral-associated adverse events, such as abacavir hypersensitivity reactions, nevirapine-associated hepatotoxicity, tenofovir-associated renal toxicity, and zidovudine-related anemia

• Describe the pharmacokinetics of NNRTI-based and dual- and triple-PI-based regimens, and the effects on virologic outcome

Earn CME credit by reading the expert analysis and commentary on Pharmacology and Adverse Drug Effects. Topics covered include:

• Relationship Between NNRTI Pharmacokinetics and Treatment Outcome
• Considerations for Therapeutic Drug Monitoring
• Use of Amprenavir or Fosamprenavir With Lopinavir/Ritonavir
• Pharmacokinetics of Atazanavir/Saquinavir Dual-PI Regimens
• Considerations for Pharmacokinetics of CCR5 Inhibitors
• Interaction Between Atazanavir and Omeprazole
• Interactions Between Antiretroviral Agents and Other Medications
• Abacavir Hypersensitivity Reaction
• Nevirapine-Associated Hepatotoxicity
• Other Adverse Effects