Learning Objectives
Upon completion of this activity, participants should be able to:
Outline the major advances leading to the current state of knowledge regarding drug-induced hepatotoxicity.
Discuss regulatory procedures involved in drug development and approval with regard to assessment of hepatotoxicity.
Describe the hepatotoxic potential and signature for several commonly used drugs.
Content includes:
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Spectrum of Hepatotoxicity Induced by Drugs
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Diagnosis of Drug-Induced Hepatic Injury
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Factors That Affect Susceptibility to Drug-Induced Liver Disease
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Mechanisms of Hepatotoxicity
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Specific Drugs of Special Interest to Hepatologists
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Isoniazid
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Hepatotoxicity From Herbal Compounds and Vitamin A
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Vitamin A (Retinol)
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Hepatic Injury From Drugs Used in the Treatment of Patients With HIV Infection and Coinfected With Hepatitis B and/or C