Learning Objectives
Upon completion of this activity, participants should be able to:
Review strategies for the diagnosis of nonalcoholic fatty liver disease
Discuss the association between nonalcoholic fatty liver disease and insulin resistance
Describe optimal management of nonalcoholic fatty liver disease and emerging pharmacologic treatments for nonalcoholic steatohepatitis
Content includes:
- Relationship of Insulin Resistance with NAFLD
- Metabolic and Biochemical Consequences of Insulin Resistance
- Insulin Resistance and the Development of a Fatty Liver
- From Fatty Liver to Steatohepatitis: Insulin Resistance and the Two-Hit Hypothesis
- Role of Mitochondria
- Cytochrome P-450
- Other Factors Produced by Hepatocytes or Adjacent Cells
- Role of Antioxidant Mechanisms
- How Oxidative Stress Produces the Phenotype of Steatohepatitis
- Determining NAFLD Diagnosis
- Management of NAFLD
- Pharmacologic Treatment of NASH: Insulin Resistance Drugs
- Lipid-Lowering Agents
- Drugs That Protect Hepatocytes