Module

Insulin Resistance and Hepatic Steatosis in Patients With Chronic Hepatitis C

Source: Hepatitis Annual Update 2007

Insulin Resistance and Hepatic Steatosis in Patients With Chronic Hepatitis C

Faculty:
Stephen A. Harrison, MD, LTC, MC

CME CREDIT INFORMATION

Release Date: 08/07/07

Expiration Date: 08/06/08

Physicians: maximum of 1.0 AMA PRA Category 1 Credit(s)™

Pharmacists: 1.0 contact hour (0.1 CEUs)

Registered Nurses: 1.0 Nursing CE credit

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Learning Objectives

Upon completion of this activity, participants should be able to:

Describe the prevalence of fatty liver and its association with obesity and insulin resistance in patients with chronic hepatitis C
Summarize the impact of obesity, insulin resistance, and steatosis on the natural history of chronic hepatitis C
Discuss the outcome of insulin-based therapy in chronic hepatitis C patients with insulin resistance and/or steatosis

Topics covered include:

Introduction
Pathogenesis of Insulin Resistance and Steatosis and the Impact of Obesity in HCV Infection
Chronic Hepatitis C, Insulin Resistance, and Type 2 Diabetes
Genotype 3 HCV and the Risk of Developing Steatosis
Oxidative Stress and Mitochondrial Dysfunction
Liver Disease Progression in the Setting of Insulin Resistance and Hepatic Steatosis
Effect of Insulin Resistance and Steatosis on Response to Interferon-Based Therapy
Potential Mechanisms Underlying Reduced Virologic Clearance
Concomitant Therapies to Improve HCV Therapy Response: Antioxidant Therapy
Concomitant Therapies to Improve HCV Therapy Response: Modulating Lipid Metabolism and Weight Loss
Concomitant Therapies to Improve HCV Therapy Response: Insulin-Sensitizing Agents
Summary of Implications for Clinical Practice

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