2022 ASCO Annual Meeting

June 3-7, 2022; Chicago, Illinois
Review slidesets and expert analyses of key data from the 2022 Clinical Oncology Annual Scientific Meeting!

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Program Content

10 Capsule Summary Slidesets

Activities

RELATIVITY-047: Subgroup Analysis
RELATIVITY-047: OS and ORR by Key Subgroups in Patients With Advanced Melanoma Receiving First-line Relatlimab + Nivolumab vs Nivolumab Alone
Conference Coverage
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Released: June 09, 2022

Expires: June 08, 2023

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NeoTrio
NeoTrio: Neoadjuvant Pembrolizumab Alone, Combined With, or in Sequence With Dabrafenib and Trametinib in Resectable BRAFV600-Mutant Stage III Melanoma
Conference Coverage
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Released: June 09, 2022

Expires: June 08, 2023

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SWOG 1512
SWOG 1512: Phase II Study of Neoadjuvant Pembrolizumab in Patients With Resectable Desmoplastic Melanoma
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Released: June 10, 2022

Expires: June 09, 2023

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KEYNOTE-716 Update
KEYNOTE-716: Update of the Phase III Trial of Adjuvant Pembrolizumab vs Placebo in Stage IIB/IIC Melanoma
Conference Coverage
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Released: June 10, 2022

Expires: June 09, 2023

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Tebentafusp + Anti–PD-L1: Cutaneous Melanoma
Tebentafusp ± Durvalumab and/or Tremelimumab in Metastatic Cutaneous Melanoma: Updated OS Analysis From IMCgp100-201 Trial
Conference Coverage
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Released: June 13, 2022

Expires: June 12, 2023

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PRADO
PRADO: Phase II Trial of Response-Directed Surgery and Adjuvant Therapy Following Neoadjuvant Ipilimumab and Nivolumab in Stage III Melanoma
Conference Coverage
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Released: June 13, 2022

Expires: June 12, 2023

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CAM/APA/TMZ in Acral Melanoma
First-line Camrelizumab, Apatinib, and Temozolomide in Advanced Acral Melanoma
Conference Coverage
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Released: June 13, 2022

Expires: June 12, 2023

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TRICOTEL
TRICOTEL: Phase II Study of Atezolizumab, Cobimetinib, and Vemurafenib in BRAFV600-Mutated Melanoma With CNS Metastases
Conference Coverage
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Released: June 15, 2022

Expires: June 14, 2023

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CheckMate 067: 7.5-Yr Update
CheckMate 067: Long-term Survival and HRQoL With First-line Nivolumab ± Ipilimumab in Advanced Melanoma at 7.5-Yr Follow-up
Conference Coverage
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Released: June 16, 2022

Expires: June 15, 2023

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AMBER Parts 1C and 1E
AMBER Parts 1C and 1E: Phase I Trial of Cobolimab, an Anti–TIM-3 mAb, Plus Dostarlimab in Advanced Melanoma
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Released: June 20, 2022

Expires: June 19, 2023

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Activities

ASCO 2022: Key Skin Cancer Studies
Key Studies in Skin Cancer: Independent Conference Coverage of the 2022 ASCO Annual Meeting
Conference Coverage
Text Module
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Released: August 29, 2022

Expires: August 28, 2023

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22 Capsule Summary Slidesets

Activities

Glofitamab in R/R DLBCL
Pivotal Phase II Trial of Glofitamab in R/R DLBCL
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Released: June 05, 2022

Expires: June 04, 2023

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Ponatinib/Blinatumomab in ALL
Phase II Trial of Ponatinib + Blinatumomab in Adults With Ph+ ALL
Conference Coverage
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Released: June 06, 2022

Expires: June 05, 2023

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ROSEWOOD
ROSEWOOD Primary Analysis: Phase II Trial of Zanubrutinib and Obinutuzumab vs Obinutuzumab Alone in R/R Follicular Lymphoma
Conference Coverage
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Released: June 06, 2022

Expires: June 05, 2023

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ELEVATE-TN: 5-Yr Update
ELEVATE-TN: 5-Yr Update of Acalabrutinib ± Obinutuzumab vs Obinutuzumab + Chlorambucil in Treatment-Naive CLL
Conference Coverage
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Released: June 07, 2022

Expires: June 06, 2023

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SHINE
SHINE: First-line Ibrutinib + Bendamustine/Rituximab Followed by Rituximab Maintenance in Older Patients With MCL
Conference Coverage
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Released: June 07, 2022

Expires: June 06, 2023

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MajesTEC-1 Update
MajesTEC-1: Update From Phase I/II Trial of the BCMA x CD3 Bispecific Antibody Teclistamab in Patients With Relapsed/Refractory Multiple Myeloma
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Released: June 07, 2022

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ECHELON-1 OS Analysis
ECHELON-1: OS Analysis of First-line Brentuximab Vedotin + AVD vs ABVD in Advanced Classical Hodgkin Lymphoma
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Released: June 07, 2022

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ASCEMBL 96-Wk Update
ASCEMBL: 96-Wk Update of Asciminib vs Bosutinib for CML-CP Previously Treated With ≥2 TKIs
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Released: June 09, 2022

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ASCEND: 4-Yr Update
ASCEND: 4-Yr Follow-up Analysis of Acalabrutinib vs Rituximab + Idelalisib or Bendamustine in Relapsed/Refractory CLL
Conference Coverage
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Released: June 09, 2022

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ATLAS: Post-ASCT KRd
Phase III ATLAS Trial of Carfilzomib, Lenalidomide, and Dexamethasone vs Lenalidomide Alone as Maintenance After ASCT in Patients With NDMM
Conference Coverage
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Released: June 09, 2022

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GC012F Phase I
First-in-Human Study of GC012F: BCMA/CD19 Dual-Targeted CAR T-Cell Therapy for Relapsed/Refractory Myeloma
Conference Coverage
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Released: June 09, 2022

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Magrolimab + Aza for AML
Phase Ib Trial of Frontline Anti-CD47 Antibody Magrolimab + Azacitidine in TP53-Mutated AML
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Released: June 10, 2022

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DETERMINATION
DETERMINATION: Phase III Trial of VRd ± ASCT With Ongoing Lenalidomide Maintenance in Patients With NDMM
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Released: June 10, 2022

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CAPTIVATE: FD Cohort 3-Yr Update
CAPTIVATE: 3-Yr Follow-up Analysis From the Fixed-Duration Cohort of First-line Ibrutinib + Venetoclax for CLL/SLL
Conference Coverage
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Released: June 10, 2022

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IDHENTIFY by <i>IDH2</i> Variant
Phase III IDHENTIFY Trial of Enasidenib vs Conventional Care in Late-Stage IDH2-Mutated R/R AML: Analysis by IDH2 Mutation
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Released: June 13, 2022

Expires: June 12, 2023

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Dual Anti–PD-1/Anti–LAG-3 in cHL
Phase I/II Study of Pembrolizumab + Favezelimab, an Anti–LAG-3 mAb, in R/R Classical Hodgkin Lymphoma
Conference Coverage
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Released: June 15, 2022

Expires: June 14, 2023

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Zilovertamab + Ibr in MCL or CLL
Phase I/II Trial of Zilovertamab, an Anti-ROR1 Antibody, Plus Ibrutinib in MCL or CLL
Conference Coverage
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Released: June 15, 2022

Expires: June 14, 2023

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EPCORE NHL-2: R/R FL
Epcoritamab, a CD3 x CD20 Bispecific Antibody, Plus R2 in R/R Follicular Lymphoma: Updated Analysis of Phase I/II EPCORE NHL-2 Trial
Conference Coverage
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Released: June 16, 2022

Expires: June 15, 2023

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EPCORE NHL-2: DLBCL
Epcoritamab, a CD3 x CD20 Bispecific Antibody, Plus R-CHOP in Untreated High-Risk DLBCL: Updated Analysis of Phase I/II EPCORE NHL-2 Trial
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Released: June 16, 2022

Expires: June 15, 2023

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Crenolanib + 7+3 in AML
Phase II Trial of Crenolanib and 7+3 Chemotherapy in Newly Diagnosed FLT3-Mutated AML: Long-term Results
Conference Coverage
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Released: June 17, 2022

Expires: June 16, 2023

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Pre-MEASURE: MRD in AML pre-alloHCT
Pre-MEASURE: Retrospective Analysis of the Prognostic Significance of NGS-MRD Testing in Patients With AML in First Remission Prior to Allogeneic HCT
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Released: June 17, 2022

Expires: June 16, 2023

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Mini-HCVD + INO ± Blina in B-ALL
Mini-HyperCVD + Inotuzumab Ozogamicin ± Blinatumomab in Older Adults With Newly Diagnosed Ph-Negative B-Cell ALL: Updated Phase II Results
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Activities

Hematologic Malignancies Highlights: ASCO 2022
Key Studies in Hematologic Malignancies: Independent Conference Coverage of the 2022 ASCO Annual Meeting
Conference Coverage
Text Module
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Released: September 13, 2022

Expires: September 12, 2023

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10 Capsule Summary Slidesets

Activities

HIMALAYA: PRO Analysis
HIMALAYA: Patient-Reported Outcomes for Patients With Unresectable Hepatocellular Carcinoma Receiving Durvalumab ± Tremelimumab
Conference Coverage
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Released: June 06, 2022

Expires: June 05, 2023

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TOPAZ-1: PRO Data
TOPAZ-1: Patient-Reported Outcomes From the Phase III Placebo-Controlled Trial of Durvalumab + Gemcitabine + Cisplatin for Advanced Biliary Tract Cancer
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Released: June 09, 2022

Expires: June 08, 2023

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PARADIGM
PARADIGM: Panitumumab + mFOLFOX6 vs Bevacizumab + mFOLFOX6 as First-line Treatment for mCRC With Wild-Type RAS
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Released: June 09, 2022

Expires: June 08, 2023

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TRIPLETE
TRIPLETE: Phase III Trial of First-line mFOLFOXIRI + Panitumumab vs mFOLFOX6 + Panitumumab in RAS/BRAF Wild-Type mCRC
Conference Coverage
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Released: June 09, 2022

Expires: June 08, 2023

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CheckMate 142: 5-Yr Update
CheckMate 142: 5-Yr Follow-up With Nivolumab ± Ipilimumab for MSI-H/dMMR Metastatic CRC
Conference Coverage
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Released: June 09, 2022

Expires: June 08, 2023

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HERB: T-DXd for BTC
HERB: Single-Arm Phase II Trial of Trastuzumab Deruxtecan for Unresectable or Recurrent HER2-Expressing Biliary Tract Cancers
Conference Coverage
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Released: June 09, 2022

Expires: June 08, 2023

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CONKO-007: CRT vs CT
CONKO-007: Chemoradiotherapy vs Chemotherapy Alone for Unresectable Locally Advanced Pancreatic Cancer
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Released: June 10, 2022

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CAIRO5
CAIRO5: FOLFOXIRI + Bevacizumab vs FOLFOX/FOLFIRI + Bevacizumab in Patients With Initially Unresectable Colorectal Liver Metastases and Right-Sided and/or RAS/BRAFV600E-Mutated Primary Tumors
Conference Coverage
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Released: June 10, 2022

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CheckMate 648: Expanded Analysis
CheckMate 648: Expanded Analysis of First-line Nivolumab + CT vs Nivolumab/Ipilimumab vs CT in Advanced Esophageal Squamous Cell Carcinoma
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Released: June 13, 2022

Expires: June 12, 2023

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Dostarlimab in dMMR Rectal Cancer
Phase II Study of Dostarlimab in Locally Advanced, Mismatch Repair–Deficient Rectal Cancer
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Released: June 14, 2022

Expires: June 13, 2023

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Activities

ASCO 2022 GI Cancers
Key Studies in Gastrointestinal Cancers: Independent Conference Coverage of the 2022 ASCO Annual Meeting
Conference Coverage
Text Module
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Released: August 31, 2022

Expires: August 30, 2023

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14 Capsule Summary Slidesets

Activities

DESTINY-Breast04
DESTINY-Breast04: Trastuzumab Deruxtecan vs Physician’s Choice of Chemotherapy for Previously Treated HER2-Low Advanced Breast Cancer
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Released: June 08, 2022

Expires: June 07, 2023

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TROPiCS-02
TROPiCS-02: Phase III Trial of Sacituzumab Govitecan vs Physician’s Choice Treatment for HR+/HER2- Advanced Breast Cancer
Conference Coverage
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Released: June 08, 2022

Expires: June 07, 2023

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KEYNOTE-826: Subgroup Analysis
KEYNOTE-826: Subgroup Analysis of Pembrolizumab + Chemotherapy ± Bevacizumab in Persistent, Recurrent, or Metastatic Cervical Cancer
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Released: June 09, 2022

Expires: June 08, 2023

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MAINTAIN
MAINTAIN: Phase II Study of Switching ET ± Ribociclib for HR+/HER2- Metastatic Breast Cancer After Failure of Previous ET + CDK4/6i
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Released: June 09, 2022

Expires: June 08, 2023

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FAKTION Update
FAKTION: Updated and Expanded Analysis of Fulvestrant + Capivasertib or Placebo After Aromatase Inhibitor Therapy in ER+/HER2- Advanced Breast Cancer
Conference Coverage
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Released: June 09, 2022

Expires: June 08, 2023

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innovaTV 205
ENGOT Cx8/GOG 3024/innovaTV 205: Interim Phase II Results With Tisotumab Vedotin Combinations in Recurrent or Metastatic Cervical Cancer
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Released: June 09, 2022

Expires: June 08, 2023

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PALOMA-2: Final OS
PALOMA-2 Final OS Analysis: Addition of Palbociclib to Frontline Letrozole in Postmenopausal ER+/HER2- Advanced Breast Cancer
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Released: June 10, 2022

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GARNET: Dostarlimab in EC
GARNET: Update From Phase I Trial of Dostarlimab in Patients With Advanced or Recurrent dMMR/MSI-H or pMMR/MSS Endometrial Cancer
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Released: June 10, 2022

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ORZORA OS Results
ORZORA: OS Results With Maintenance Olaparib in Platinum-Sensitive Relapsed Ovarian Cancer With a BRCA Mutation or Other HRR Mutation
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Released: June 13, 2022

Expires: June 12, 2023

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ATHENA-MONO
ATHENA-MONO: Phase III Trial of Maintenance Rucaparib vs Placebo After First-line Platinum-Based Chemotherapy in Advanced Ovarian Cancer
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Released: June 14, 2022

Expires: June 13, 2023

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KEYNOTE-522: EFS by RCB
KEYNOTE-522: Exploratory Analysis of EFS by Residual Cancer Burden With Neoadjuvant Pembrolizumab + Chemotherapy for Early TNBC
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Released: June 14, 2022

Expires: June 13, 2023

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Relacorilant in PROC
Relacorilant, a Selective Glucocorticoid Receptor Modulator, Plus Nab-Paclitaxel in Recurrent Platinum-Resistant Ovarian Cancer: OS Analysis From a Randomized Phase II Trial
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Released: June 15, 2022

Expires: June 14, 2023

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LUMINA
LUMINA: Local Recurrence With Omission of Radiotherapy After Breast-Conserving Surgery in T1N0 Luminal A Breast Cancer
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Released: June 15, 2022

Expires: June 14, 2023

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MITO23
MITO23: Phase III Trial of Trabectedin vs Investigator’s Choice of Chemotherapy for Recurrent Ovarian Cancer With BRCA Mutation or BRCAness Phenotype
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Released: June 17, 2022

Expires: June 16, 2023

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Activities

ASCO 2022: Key Studies
An Expert’s Guide to ASCO 2022: Preview of the Top Abstracts
Clinical Thought
Conference Coverage
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Released: June 01, 2022

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ASCO 2022 Breast/Gyn
Key Studies in Breast and Gynecologic Cancers: Independent Conference Coverage of the 2022 ASCO Annual Meeting
Conference Coverage
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Released: August 17, 2022

Expires: August 16, 2023

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13 Capsule Summary Slidesets

Activities

KRYSTAL-1
KRYSTAL-1 Trial of Adagrasib in Patients With Previously Treated Advanced KRASG12C-Mutated NSCLC: Analysis of Registrational Phase II Cohort
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Released: June 06, 2022

Expires: June 05, 2023

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TACTI-002
Phase II TACTI-002 Trial: Updated Results With Eftilagimod Alpha Plus Pembrolizumab as First-line Therapy in Advanced NSCLC
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Released: June 07, 2022

Expires: June 06, 2023

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ATLANTIS Lurbinectedin Monotherapy
ATLANTIS: Analysis of Outcomes With Single-Agent Lurbinectedin After Lurbinectedin + Doxorubicin in Relapsed SCLC
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Released: June 08, 2022

Expires: June 07, 2023

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SKYSCRAPER-02
SKYSCRAPER-02: Phase III Trial of First-line Atezolizumab + Carboplatin/Etoposide ± Tiragolumab, an Anti-TIGIT Antibody, in ES-SCLC
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Released: June 09, 2022

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OPAL: 1L Osi + CT in NSCLC
OPAL: Phase II Trial of First-line Osimertinib Plus Platinum-Based Doublet Chemotherapy in EGFR-Mutated Advanced NSCLC
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Released: June 09, 2022

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Patritumab Deruxtecan in Adv NSCLC
Phase I Trial of Patritumab Deruxtecan for Previously Treated Advanced NSCLC Without EGFR Activating Mutations
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Released: June 09, 2022

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CLN-081: <i>EGFR</i> ex20ins+ NSCLC
Updated Results of a Phase I/IIa Trial of CLN-081, a Selective EGFR TKI, in Advanced NSCLC Harboring EGFR Exon 20 Insertion Mutations
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Released: June 10, 2022

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CheckMate 816 Post Hoc EFS Analysis
CheckMate 816: Association of Pathologic Regression With EFS for Neoadjuvant Nivolumab + CT in Resectable NSCLC
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Released: June 10, 2022

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CHRYSALIS: Ami for <i>MET</i>ex14+ NSCLC
CHRYSALIS: Updated Phase I Trial Results of Amivantamab in Advanced NSCLC With MET Exon 14 Skipping Mutations
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Released: June 10, 2022

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NADIM II: Neoadj Nivo + CT
NADIM II: Phase II Trial of Neoadjuvant Nivolumab + Chemotherapy vs Chemotherapy in Resectable Stage IIIA/B NSCLC
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Released: June 10, 2022

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KRYSTAL-1 CNS Cohort
KRYSTAL-1: Phase Ib Report of Adagrasib Activity in Patients With KRAS G12C–Mutated NSCLC and Active, Untreated CNS Metastases
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Released: June 13, 2022

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CHRYSALIS-2 Update
CHRYSALIS-2: Update of Amivantamab + Lazertinib in EGFR-Mutant NSCLC After Progression on Osimertinib and Chemotherapy
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Released: June 14, 2022

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ATEZO-BRAIN Update
Phase II ATEZO-BRAIN: Updated Results With Atezolizumab + Carboplatin/Pemetrexed in Advanced Nonsquamous NSCLC With Untreated Brain Metastases
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Released: June 16, 2022

Expires: June 15, 2023

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Activities

Lung Cancer Highlights: ASCO 2022
Key Studies in Lung Cancer: Independent Conference Coverage of ASCO 2022
Conference Coverage
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Released: September 01, 2022

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Faculty

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Allison Betof Warner, MD, PhD

Assistant Professor of Medicine (Oncology)
Director, Melanoma Medical Oncology Program
Director, Solid Tumor Cellular Therapy 
Leader, Melanoma & Cutaneous Oncology Clinical Research Group
Stanford University School of Medicine
Stanford, California

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John M. Burke, MD

Associate Chair
US Oncology Hematology Research Program
Rocky Mountain Cancer Centers
Aurora, Colorado

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Shaji K. Kumar, MD

Mark and Judy Mullins Professor of Hematological Malignancies
Chair, Myeloma Amyloidosis Dysproteinemia Group
Consultant, Division of Hematology
Mayo Clinic
Rochester, Minnesota

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Christopher H. Lieu, MD

Associate Professor
Associate Director for Clinical Research
Division of Medical Oncology
University of Colorado Cancer Center
Co-Director, GI Medical Oncology
Division of Medical Oncology
University of Colorado Hospital
Aurora, Colorado

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Stephen V. Liu, MD

Associate Professor of Medicine
Director, Thoracic Oncology
Head, Developmental Therapeutics
Georgetown University
Washington, DC

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Joyce O'Shaughnessy, MD

Celebrating Women Chair in Breast Cancer Research
Baylor University Medical Center
Chair, Breast Disease Committee
Texas Oncology
Sarah Cannon Research Institute
Dallas, Texas

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Zofia Piotrowska, MD

Assistant Professor of Medicine
Massachusetts General Hospital Cancer Center
Harvard Medical School
Boston, Massachusetts

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Angeles Alvarez Secord, MD, MHSc

Professor
Division of Gynecologic Oncology
Department of OB/GYN
Duke Cancer Institute
Duke University Health System
Durham, North Carolina

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Rachna Shroff, MD, MS

Professor of Medicine
Chief, Section of GI Medical Oncology
Director, UACC Clinical Trials Office
The University of Arizona Cancer Center
Tucson, Arizona

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Hussein Tawbi, MD

Associate Professor of Medicine
Division of Hematology/Oncology
Department of Medicine
University of Pittsburgh Cancer Institute
Pittsburgh, Pennsylvania

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Hussein Tawbi, MD, PhD

Professor
Department of Melanoma Medical Oncology
The University of Texas MD Anderson Cancer Center
Houston, Texas

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Eunice S. Wang, MD

Chief, Leukemia/Benign Hematology Service
Professor of Oncology
Roswell Park Comprehensive Cancer Center
Buffalo, New York

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Supporters

Supported by educational grants from

AbbVie

AstraZeneca

AstraZeneca

Bristol Myers Squibb

Daiichi Sankyo, Inc.

Gilead Sciences, Inc.

GlaxoSmithKline

Jazz Pharmaceuticals Inc

Merck Sharp & Dohme Corp.

Novartis Pharmaceuticals Corporation

Seagen

Seagen and Genmab