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Medical Minute 2: Putting It Into Practice: Where Do S1P Receptor Modulators Fit?


This Medical Minute will have a key focus on S1P receptor modulators, addressing how to select optimal therapy for ulcerative colitis based on clinical trial data, guidelines, and shared decision-making.

Physicians: Maximum of 0.50 AMA PRA Category 1 Credit

Released: March 13, 2023

Expiration: March 12, 2024

No longer available for credit.



Jordan Axelrad

Jordan Axelrad, MD, MPH

Associate Professor
NYU Grossman School of Medicine
Clinical and Translational Research
Inflammatory Bowel Disease Center at NYU Langone Health
New York, New York

Provided by

ProCE Banner


This activity is supported by an educational grant from

Bristol Myers Squibb

Target Audience

This educational program is intended for gastroenterologists, gastroenterology nurse practitioners and physician associates/physician assistants, primary care providers, and other healthcare professionals involved in the care of patients with UC.

Program Learning Goal

The goal of this program is to improve learner knowledge, competence, and performance regarding a treat-to-target approach in UC, the latest efficacy and safety data for agents targeting S1P, and treatment positioning for S1P receptor modulators to optimize UC management.

Learning Objectives

After completing this activity, participants should be better able to:

  • Examine current and emerging S1P receptor modulators, their mechanisms of action, and pharmacodynamic properties

  • Select optimal therapy for patients with UC based on clinical trial data, evidence-based guidelines, and shared decision-making


Clinical Care Options, LLC (CCO) requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose all financial conflicts of interest (COI) they may have with ineligible companies. All relevant COI are thoroughly vetted and mitigated according to CCO policy. CCO is committed to providing its learners with high-quality CME/CE activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of an ineligible company.

The faculty reported the following relevant financial relationships or relationships to products or devices they have with ineligible companies related to the content of this educational activity:

Jordan Axelrad, MD, MPH: consultant/advisor/speaker: AbbVie, Adiso, Bristol-Myers Squibb, Fresenius, Janssen, Pfizer.

The planners and content peer reviewers from Clinical Care Options, LLC do not have any relevant financial relationships to disclose.

Instructions for Credit

Participation in this self-study activity should be completed in approximately 0.5 hours. To successfully complete this activity and receive credit, participants must follow these steps during the period from March 13, 2023, through March 12, 2024:

1. Register online at
2. Read the target audience, learning objectives, and faculty disclosures.
3. Study the educational activity online or printed out.
4. Submit answers to the posttest questions and evaluation questions online.

You must receive a test score of at least 65% and respond to all evaluation questions to receive a certificate. After submitting the evaluation, you may access your online certificate by selecting the certificate link on the posttest confirmation page. Records of all CME/CE activities completed can be found on the "CME/CE Manager" page. There are no costs/fees for this activity.


This program has been made available online.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.


Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.


Joint Accreditation Statement
Joint Accreditation



In support of improving patient care, Clinical Care Options, LLC (CCO) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physician Continuing Medical Education

Credit Designation
CCO designates this enduring material for a maximum of 0.50 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.