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Phase Ib Trial of Frontline Anti-CD47 Antibody Magrolimab + Azacitidine in TP53-Mutated AML

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In this single-arm study, magrolimab plus azacitidine had a tolerable safety profile and achieved a CR rate of 33% in the frontline treatment of patients with TP53-mutated AML not eligible for intensive induction therapy.

Released: June 10, 2022

Expiration: June 09, 2023

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Supported by educational grants from

AbbVie

AstraZeneca

AstraZeneca

Bristol Myers Squibb

Daiichi Sankyo, Inc.

Gilead Sciences, Inc.

GlaxoSmithKline

Jazz Pharmaceuticals Inc

Merck Sharp & Dohme Corp.

Novartis Pharmaceuticals Corporation

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Seagen and Genmab