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Targeting TIGIT: A Novel Mechanism to Inhibit the Immune Checkpoint Pathway

Clinical Thought
In this commentary, Diwakar Davar, MD, and Jyoti D. Patel, MD, review TIGIT as a therapeutic target and discuss data from key clinical trials, including the TIGIT inhibitor tiragolumab in NSCLC.

Released: April 14, 2022

Expiration: April 13, 2023

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Faculty

Diwakar Davar

Diwakar Davar, MD

Assistant Professor
Melanoma and Phase I Therapeutics
Division of Hematology/Oncology
Department of Medicine
University of Pittsburgh Hillman Cancer Center
Pittsburgh, Pennsylvania

Jyoti D. Patel

Jyoti D. Patel, MD

Professor of Medicine
Division of Hematology and Oncology
Medical Director for Thoracic Oncology
Assistant Director for Clinical Research
Associate Vice Chair of Clinical Research
Department of Medicine
Robert H. Lurie Comprehensive Cancer Center
Northwestern University
Chicago, Illinois

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Supported by an educational grant from

Genentech, a member of the Roche Group

Faculty Disclosure

Primary Author

Diwakar Davar, MD

Assistant Professor
Melanoma and Phase I Therapeutics
Division of Hematology/Oncology
Department of Medicine
University of Pittsburgh Hillman Cancer Center
Pittsburgh, Pennsylvania

Diwakar Davar, MD, has disclosed that he has received funds for research support from Arcus, CellSight Technologies, Checkmate Pharmaceuticals, GlaxoSmithKline/Tesaro, Immunocore, and Merck and consulting fees from Checkmate Pharmaceuticals, Finch, Shionogi, and Vedanta.

Jyoti D. Patel, MD

Professor of Medicine
Division of Hematology and Oncology
Medical Director for Thoracic Oncology
Assistant Director for Clinical Research
Associate Vice Chair of Clinical Research
Department of Medicine
Robert H. Lurie Comprehensive Cancer Center
Northwestern University
Chicago, Illinois

Jyoti D. Patel, MD, has disclosed that she has received funds for research support from AstraZeneca and consulting fees from AbbVie and Takeda.