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Insights on Newer Oral Therapy Options for Ulcerative Colitis

Clinical Thought

Here, I provide my thoughts on S1P receptor modulators and JAK inhibitors in managing UC, including practical considerations about applying research outcomes, the ideal therapeutic placement for each class, and key clinical considerations about how these agents are advancing patient care.

ABIM MOC: maximum of 0.25 Medical Knowledge MOC point

Physician Assistants/Physician Associates: 0.25 AAPA Category 1 CME credit

Nurses: 0.25 Nursing contact hour

Physicians: maximum of 0.25 AMA PRA Category 1 Credit

Released: November 22, 2023

Expiration: November 21, 2024

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Marla Dubinsky

Marla Dubinsky, MD

Professor of Pediatrics and Medicine
Chief, Division of Pediatric GI and Nutrition
Co-Director, Susan and Leonard Feinstein IBD Center
Icahn School of Medicine, Mount Sinai New York
New York, New York

Provided by

Provided by Clinical Care Options, LLC

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Supported by an educational grant from Pfizer, Inc.

Pfizer, Inc.

Target Audience

This educational program is intended for gastroenterologists, internal medicine specialists, primary care physicians, nurses, physician associates and other HCPs involved in the diagnosis, treatment, and management of patients with UC.

Program Learning Goal

The goal of this program is to improve learner knowledge and competence in the latest efficacy and safety data for agents targeting S1P, treatment positioning for S1P receptor modulators, and the implications of JAK inhibitor selectivity for optimizing UC management.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Detail the mechanism of action and pharmacodynamic properties of S1P receptor modulators

  • Explore potential approaches for positioning S1P receptor modulator therapies for patients with UC

  • Differentiate the selectivity, safety, and efficacy of current and emerging JAK inhibitors


Clinical Care Options, LLC (CCO) requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose all financial conflicts of interest (COI) they may have with ineligible companies. All relevant COI are thoroughly vetted and mitigated according to CCO policy. CCO is committed to providing its learners with high-quality CME/CE activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of an ineligible company.

The faculty reported the following relevant financial relationships or relationships to products or devices they have with ineligible companies related to the content of this educational activity:

Primary Author

Marla Dubinsky, MD

Professor of Pediatrics and Medicine
Chief, Division of Pediatric GI and Nutrition
Co-Director, Susan and Leonard Feinstein IBD Center
Icahn School of Medicine, Mount Sinai New York
New York, New York

Marla Dubinsky, MD: consultant/advisor/speaker: AbbVie, Abivax, AstraZeneca, Bristol Myers Squibb, Janssen, Lilly, Merck, Pfizer, Prometheus Biosciences, Takeda.

The planners and content peer reviewers from Clinical Care Options, LLC do not have any relevant financial relationships to disclose, except Kimberly Kearns, MS, APRN, ANP-BC, as noted below.

Kimberly Kearns, MS, APRN, ANP-BC: consultant/advisor/speaker: AbbVie, Ardelyx, Bristol Myers Squibb, Janssen, Lilly, Medtronic, Pfizer, Salix, Takeda.

Instructions for Credit

Participation in this self-study activity should be completed in approximately 0.25 hours. To successfully complete this activity and receive credit, learners must follow these steps during the period from November 22, 2023, through November 21, 2024:

  1. Login or Sign Up for an account by clicking at the top of this page.
  2. Read the target audience, learning objectives, and faculty disclosures.
  3. View and study the content in its entirety.
  4. Submit answers to the posttest questions and evaluation questions online.

You must receive a test score of at least 65 and respond to all evaluation questions to receive a certificate. After submitting the evaluation, you may access your online certificate by selecting the certificate link on the confirmation page. Records of all CME/CE activities completed can be found on the "My Certificates" page. There are no costs/fees for this activity.


This program has been made available online.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.


Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.


Joint Accreditation Statement
Joint AccreditationIn support of improving patient care, Clinical Care Options, LLC (CCO) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.


Physician Continuing Medical Education
CCO designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity. 

Nursing Continuing Professional Development
The maximum number of hours awarded for this Nursing Continuing Professional Development activity is 0.25 contact hour.

Physician Associate Continuing Medical Education
Joint AccreditationClinical Care Options has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 0.25 AAPA Category 1 CME credit. Approval is valid until  November 21, 2024. PAs should only claim credit commensurate with the extent of their participation.


American Board of Internal Medicine Maintenance of Certification

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 0.25 MOC point in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

For ABIM MOC points, your information will be shared with the ABIM through CCO's Joint Accreditation Program and Activity Reporting System (JAPARS). Please allow 6-8 weeks for your MOC points to appear on your ABIM records.

By sharing your Diplomate Board ID # and DOB, you are giving Clinical Care Options, LLC permission to use this information/data to report your participation to these Boards via the Joint Accreditation Program and Activity Reporting System (JA-PARS).

Completion of this accredited CME activity meets the expectations of an Accredited Safety or Quality Improvement Program (IA_PSPA_28) for the Merit-based Incentive Payment Program (MIPS).

In order to fulfill requirements for MIPS improvement activity, participants will need to fill out 2 brief follow-up surveys at 30- and 90-days post-activity.