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Rett Syndrome Today: Current Options for Symptom Management

Podcast Episodes

Listen as David N. Lieberman, MD, PhD, and Shannon Standridge, DO, MPH, provide valuable information on current management strategies for common manifestations of Rett syndrome.

Pharmacists: 0.50 contact hour (0.05 CEUs)

Physicians: Maximum of 0.50 AMA PRA Category 1 Credit

Physician Assistants/Physician Associates: 0.50 AAPA Category 1 CME credit

Nurses: 0.50 Nursing contact hour, including 0.50 hour of pharmacotherapy credit 

Released: March 02, 2023

Expiration: March 01, 2024

No longer available for credit.



David N. Lieberman

David N. Lieberman, MD, PhD

Department of Neurology
Harvard Medical School
Attending Physician
Child Neurology
Boston Childrens Hospital
Boston, Massachusetts

Shannon Standridge

Shannon Standridge, DO, MPH

Division of Neurology
Vinaya Rett Syndrome and Related Spectrum Disorders Clinic
Cincinnati Childrens Hospital Medical Center
Cincinnati, Ohio

Provided by

Provided by Clinical Care Options, LLC

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Supported by an educational grant from

Acadia Pharmaceuticals, Inc.

Target Audience

This program is intended for neurology-focused healthcare professionals caring for patients with Rett syndrome including neurologists (physicians), nurse practitioners, physician associates/physician assistants, nurses, and pharmacists.

Program Learning Goal

The goal of this program is to improve the knowledge and competence of learners in effort to optimize treatment for patients with Rett syndrome.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Recommend optimal treatment options for supportive care in Rett syndrome


Clinical Care Options, LLC (CCO) requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose all financial conflicts of interest (COI) they may have with ineligible companies. All relevant COI are thoroughly vetted and mitigated according to CCO policy. CCO is committed to providing its learners with high-quality CME/CE activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of an ineligible company.

The faculty reported the following relevant financial relationships or relationships to products or devices they have with ineligible companies related to the content of this educational activity:

David N. Lieberman, MD, PhD: consultant/advisor/speaker: Acadia Pharmaceuticals, Neurogene, Taysha Gene Therapies.

Shannon Standridge, DO, MPH: consultant/advisor/speaker: Acadia, Jazz, Marinus, Zogenix.

The planners and content peer reviewers from Clinical Care Options, LLC do not have any relevant financial relationships to disclose, except Gabrielle Giacona and Amanda Zimmerman, PA-C as noted below:

Gabrielle Giacona: individual publicly traded stocks/stock options: AstraZeneca, Moderna.

Amanda Zimmerman, PA-C: consultant/advisor/speaker: Averitas; researcher: Collegium.

Instructions for Credit

Participation in this self-study activity should be completed in approximately 0.5 hours. To successfully complete this activity and receive credit, learners must follow these steps during the period from March 02, 2023, through March 01, 2024:

  1. Create an account or Login at 
  2. Read the target audience, learning objectives, and faculty disclosures
  3. View and study the content in its entirety
  4. Submit answers to the post-test questions and evaluation questions online

You must receive a test score of at least 65% and respond to all evaluation questions to receive a certificate. After submitting the evaluation, you may access your online certificate by clicking the certificate link on the confirmation page. Records of all CME/CE activities completed can be found on the "My Certificates" page. There are no costs/fees for this activity.


This program has been made available online.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.


Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.


Joint Accreditation Statement
Joint AccreditationIn support of improving patient care, Clinical Care Options, LLC (CCO) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.


Physician Continuing Medical Education
Credit Designation

CCO designates this enduring material for a maximum of 0.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nursing Continuing Professional Development
The maximum number of hours awarded for this Nursing Continuing Professional Development activity is 0.5 contact hours.

Continuing Pharmacy Education
CCO designates this continuing education activity for 0.5 contact hours (0.05 CEUs) of the Accreditation Council for Pharmacy Education. Universal Activity Number - JA4008176-0000-23-074-H01-P.

Type of Activity: Knowledge 

Upon successfully completing the post-test with a score of 65% or better and the activity evaluation form, transcript information will be sent to the NABP CPE Monitor Service within 60 days.

Physician Assistant/Physician Associate Continuing Medical Education

Joint AccreditationClinical Care Options, LLC has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 0.5 AAPA Category 1 CME credits. Approval is valid until March 01, 2024. PAs should only claim credit commensurate with the extent of their participation.