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The Role of Brain Cholesterol Inhibition in the Treatment of Epilepsy

Clinical Thought

As the treatment landscape of epilepsy—including rare developmental and epileptic encephalopathies—evolves, novel approaches are necessary to ensure patients’ quality of life are not severely impacted by adverse events. The cholesterol 24-hydroxylase inhibitor soticlestat shows promise in reducing frequency and severity of seizures, while being highly tolerable compared to placebo.

Released: September 15, 2023

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Jonathan J. Halford

Jonathan J. Halford, MD

Director, Translational Research Unit
Department of Neurology
Medical University of South Carolina
Charleston, South Carolina

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Provided by Clinical Care Options, LLC

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Supported by an educational grant from Takeda Pharmaceuticals U.S.A., Inc. 

Takeda Pharmaceuticals U.S.A., Inc.