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Rational Combination Strategies in the Treatment of EGFR-Mutated NSCLC With Acquired Resistance to EGFR TKI Therapy: Updates From ASCO 2022

Clinical Thought
In this commentary, a lung cancer expert highlights advances from ASCO 2022 in the management of EGFR-mutated NSCLC with acquired resistance to first-line EGFR TKI therapy using rational combination regimens composed of third-generation EGFR TKIs, EGFR monoclonal antibodies, bispecific antibodies, and antibody–drug conjugates.

Released: July 13, 2022

Expiration: July 12, 2023

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Faculty

Jonathan Riess

Jonathan Riess, MD, MS

Associate Professor
Division of Hematology-Oncology
Department of Internal Medicine
UC Davis
Medical Director
Thoracic Oncology
UC Davis Comprehensive Cancer Center
Sacramento, California

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Faculty Disclosure

Primary Author

Jonathan Riess, MD, MS

Associate Professor
Division of Hematology-Oncology
Department of Internal Medicine
UC Davis
Medical Director
Thoracic Oncology
UC Davis Comprehensive Cancer Center
Sacramento, California

Jonathan Riess, MD, MS: consultant/advisor/speaker: BeiGene, Blueprint, Boehringer Ingelheim, Bristol Myers Squibb, Daiichi Sankyo, Genentech, Janssen, Jazz, Novartis, Regeneron; researcher: AstraZeneca, GlaxoSmithKline, Merck, Novartis, Revolution Medicines, Spectrum.