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Trastuzumab Deruxtecan for Brain Metastases in HER2-Positive Metastatic Breast Cancer: A Pooled Analysis of DESTINY-Breast01, 02, and 03 Trials

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In this retrospective pooled analysis of the DESTINY-Breast01, 02, and 03 trials, trastuzumab deruxtecan was associated with an intracranial response rate of approximately 45% in patients with either stable or active brain metastases and demonstrated an acceptable safety profile in this population.

Released: November 01, 2023

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Supported by an educational grant from AstraZeneca, Bristol Myers Squibb, Daiichi Sankyo, Inc., Exelixis, Inc., Gilead Sciences, Inc., Lilly and Regeneron Pharmaceuticals, Inc.

AstraZeneca

Bristol Myers Squibb

Daiichi Sankyo, Inc.

Exelixis, Inc.

Gilead Sciences, Inc.

Lilly

Regeneron Pharmaceuticals, Inc