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Phase II Study of Dostarlimab in Locally Advanced, Mismatch Repair–Deficient Rectal Cancer

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Early data showed that among 14 patients with locally advanced, dMMR rectal cancer who completed treatment with the PD-1 inhibitor dostarlimab, all 14 achieved a clinical complete response, without the need for chemoradiotherapy or surgery.

Released: June 14, 2022

Expiration: June 13, 2023

No longer available for credit.


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Provided by Clinical Care Options, LLC
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Supported by educational grants from



Bristol Myers Squibb

Daiichi Sankyo, Inc.

Gilead Sciences, Inc.


Jazz Pharmaceuticals Inc

Merck Sharp & Dohme Corp.

Novartis Pharmaceuticals Corporation

Seagen and Genmab