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Frequently Asked Questions: Expanding the Spectrum of HER2 Positivity in Advanced Breast Cancer With T-DXd

Clinical Thought

Read experts’ answers to healthcare professionals’ questions on the optimal use and management of adverse events with the antibody–drug conjugate T-DXd in patients with HER2-low advanced breast cancer.

Released: February 13, 2023

Expiration: February 12, 2024

No longer available for credit.



Nadia Harbeck

Nadia Harbeck, MD, PhD

Full Professor
Breast Center, LMU University Hospital
Ludwig-Maximilians University
Munich, Germany

Komal Jhaveri

Komal Jhaveri, MD, FACP

Associate Attending
Breast Medicine Service and Early Drug Development Service
Section Head, Endocrine Therapy Research Program
Clinical Director, Early Drug Development Service
Department of Medicine
Associate Professor of Medicine
Weill Cornell Medical College
New York, New York

Heather McArthur

Heather McArthur, MD, MPH

Associate Professor
Department of Internal Medicine
Clinical Director, Breast Cancer Program
Komen Distinguished Chair in Clinical Breast Cancer Research
UT Southwestern Medical Center
Dallas, Texas

Provided by

Provided by Clinical Care Options, LLC

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Supported by educational grants from

AstraZeneca Pharmaceuticals

Daiichi Sankyo, Inc.


Nadia Harbeck, MD, PhD: consultant: AstraZeneca, Daiichi-Sankyo, Lilly, MDS, Novartis, Pierre Fabre, Pfizer, Roche, Sandoz/Hexal, Seagen; fees for non-CME/CE services: AstraZeneca, Daiichi-Sankyo, Lilly, MDS, Novartis, Pfizer, Pierre Fabre, Roche, Seagen.

Komal Jhaveri, MD: consultant/advisor/speaker: AbbVie, AstraZeneca, Blueprint Medicine, Bristol-Myers Squibb, Daiichi Sankyo, Eisai, Genentech/Roche, Gilead Sciences, Jounce Therapeutics, Lilly/Loxo Oncology, Menarini/Stemline, Novartis, Olema, Pfizer, Seagen, Sun Pharma, Taiho Oncology; researcher: AstraZeneca, Context Therapeutics, Debio, Genentech/Roche, Gilead Sciences, Lilly/Loxo, Merck, Novartis, Pfizer, Puma Biotech, Zymeworks.

Heather McArthur, MD, MPH: advisor: AstraZeneca, Bristol-Myers Squibb, Crown Bioscience, Daiichi Sankyo, Gilead Sciences, Immunomedics, Lilly, Merck, Pfizer, Puma Biotech, Seagen; researcher (paid to institution): Bristol-Myers Squibb, Merck.


This program is made available online.