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Personalized Therapy in the Era of Precision Medicine: Guidance on Histology-Agnostic Therapies for the Community Multidisciplinary Oncology Team


Watch this interactive webcast to learn about the latest histology-agnostic therapies and associated biomarkers.

Nurses: 1.00 Nursing contact hour

Physicians: maximum of 1.00 AMA PRA Category 1 Credit

Pharmacists: 1.00 contact hour (0.1 CEUs)

Released: October 04, 2023

Expiration: October 03, 2024



Razelle Kurzrock

Razelle Kurzrock, MD

Medical College of Wisconsin
Milwaukee, Wisconsin

Vivek Subbiah

Vivek Subbiah, MD

Chief, Early-Phase Drug Development
Sarah Cannon Research Institute
Nashville, Tennessee

Provided by

Provided by Clinical Care Options, LLC

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Supported by educational grants from Bayer HealthCare Pharmaceuticals Inc., Elevation Oncology, Merck Sharp & Dohme Corp., and Merus NV.

Bayer HealthCare Pharmaceuticals Inc.

Elevation Oncology

Merck Sharp & Dohme Corp.

Merus NV

Target Audience

This program is intended for physicians, nurse practitioners, physician associates/physician assistants, nurses, pharmacists, and other healthcare professionals who care for patients with malignant solid tumors.

Program Learning Goal

The goal of this activity is to improve the knowledge, confidence, and competence of oncologists, pathologists, molecular pathologists, oncology physician associates/physician assistants, oncology nurses, pharmacists, and other healthcare professionals to optimally integrate histology-agnostic therapies into treatment of eligible patients with cancer.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Order appropriate assays or molecular tests to detect BRAF V600E, microsatellite instability-high (MSI-H)/deficient mismatch repair (dMMR), tumor mutation burden–high (TMB-H), and oncogenic gene fusions in patients with malignant solid tumors

  • Appraise emerging clinical efficacy and safety data supporting the use of multitumor and histology-agnostic therapies in solid tumors

  • Formulate strategies for integrating histology-agnostic agents into the management of eligible patients with cancer based on biomarker assessment, current evidence as well as expert and guideline recommendations

  • Develop strategies for managing immune-related adverse events associated with histology-agnostic treatment with immune checkpoint inhibitors

  • Identify and refer eligible patients with appropriate biomarkers for enrollment in ongoing clinical trials


Clinical Care Options, LLC (CCO) requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose all financial conflicts of interest (COI) they may have with ineligible companies. All relevant COI are thoroughly vetted and mitigated according to CCO policy. CCO is committed to providing its learners with high-quality CME/CE activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of an ineligible company.

The faculty reported the following relevant financial relationships or relationships to products or devices they have with ineligible companies related to the content of this educational activity:

Primary Author

Razelle Kurzrock, MD

Medical College of Wisconsin
Milwaukee, Wisconsin

Razelle Kurzrock, MD: researcher: Boehringer Ingelheim, Debiopharm, Foundation Medicine, Genentech, Grifols, Guardant, Incyte, Konica Minolta, Medimmune, Merck Serono, Omniseq, Pfizer, Sequenom, Takeda, TopAlliance; consultant/advisor/speaker: Actuate, AstraZeneca, Bicara, Biological Dynamics, Caris, Datar Cancer Genetics, Daiichi, EISAI, EOM, Iylon, LabCorp, Merck, NeoGenomics, Neomed, Pfizer, Prosperdtx, Regeneron, Roche, TD2/Volastra, Turning Point Therapeutics, X-Biotech; equity interest: CureMatch; board member: CureMetrix, CureMatch.

Vivek Subbiah, MD

Chief, Early-Phase Drug Development
Sarah Cannon Research Institute
Nashville, Tennessee

Vivek Subbiah, MD: consultant/advisor/speaker: Aadi Biosciences, Bayer, Illumina, Labcorp, Pfizer, Relay Therapeutics.

The planners and content peer reviewers from Clinical Care Options, LLC do not have any relevant financial relationships to disclose, except Kristi K. Orbaugh as noted below.

Kristi K. Orbaugh, MSN, NP, AOCNP: consultant/advisor/speaker: AstraZeneca, Bristol-Myers Squibb, CTI, DSI, Gilead, Lilly, MorphoSys, Pfizer.

Instructions for Credit

Participation in this self-study activity should be completed in approximately 1 hour. To successfully complete this activity and receive credit, learners must follow these steps during the period from October 04, 2023, through October 03, 2024:

  1. Login or Sign Up for an account by clicking at the top of this page
  2. Read the target audience, learning objectives, and faculty disclosures
  3. View and study the content in its entirety
  4. Submit answers to the post-test questions and evaluation questions online

You must receive a test score of 65 or better and respond to all evaluation questions to receive a certificate. After submitting the evaluation, you may access your online certificate by selecting the certificate link on the confirmation page. Records of all CME/CE activities completed can be found on the "My Certificates" page. There are no costs/fees for this activity.


This program has been made available online.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.


Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.


Joint Accreditation Statement
Joint AccreditationIn support of improving patient care, Clinical Care Options, LLC is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team. 


Physician Continuing Medical Education

CCO designates this enduring material for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nursing Continuing Professional Development
The maximum number of hours awarded for this Nursing Continuing Professional Development activity is 1 contact hour.

Continuing Pharmacy Education

CCO designates this continuing education activity for 1 contact hour (0.1 CEUs) of the Accreditation Council for Pharmacy Education.

Universal Activity Number -  JA4008176-0000-23-247-H01-P 
Type of Activity: Application

Upon successfully completing the post-test with a score of 65% or better and the activity evaluation form, transcript information will be sent to the NABP CPE Monitor Service within 60 days.