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KRYSTAL-1: Phase Ib Report of Adagrasib Activity in Patients With KRAS G12C–Mutated NSCLC and Active, Untreated CNS Metastases

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In this small cohort of patients with KRAS G12C–mutant NSCLC and active, untreated CNS metastases, adagrasib shows encouraging clinical activity and safety, yielding objective intracranial responses in a third of patients.

Released: June 13, 2022

Expiration: June 12, 2023

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Provided by Clinical Care Options, LLC
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Supported by educational grants from



Bristol Myers Squibb

Daiichi Sankyo, Inc.

Gilead Sciences, Inc.


Jazz Pharmaceuticals Inc

Merck Sharp & Dohme Corp.

Novartis Pharmaceuticals Corporation

Seagen and Genmab