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Integrating Current Evidence and Individualized Treatment Regimens Into Clinical Practice for Patients With MPNs

Text Module

Read this expert commentary on recent advances and emerging strategies for treating patients with essential thrombocythemia, polycythemia vera, and myelofibrosis.

Pharmacists: 1.00 contact hour (0.1 CEUs)

Nurses: 1.00 Nursing contact hour

Physicians: Maximum of 1.00 AMA PRA Category 1 Credit

Released: August 21, 2023

Expiration: August 22, 2024



Prithviraj Bose

Prithviraj Bose, MD

Associate Professor
Division of Cancer Medicine
Department of Leukemia
The University of Texas MD Anderson Cancer Center
Houston, Texas

Provided by

Provided by Clinical Care Options, LLC

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Supported by educational grants from GSK, Incyte Corporation, and PharmaEssentia USA Corp.


Incyte Corporation

PharmaEssentia Corp

Target Audience

This program is intended for hematologists/oncologists, advanced practice providers, nurses, pharmacists, and other healthcare professionals involved in the treatment of patients with myeloproliferative neoplasms, including myelofibrosis, polycythemia vera, and essential thrombocythemia.

Program Learning Goal

The goal of this program is to improve the knowledge, confidence, competence, and performance of learners in the identification and treatment of MPNs in first-line and second-line treatment using evidence-based and guideline-directed best practices.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Recognize the symptoms and patterns of first-line treatment failure in patients with MPNs, including treatment intolerance and treatment resistance

  • Assess first-line treatment strategies for patients with MF with low platelet counts

  • Plan evidence-based therapeutic strategies for patients with MF who are relapsed, refractory, or intolerant to prior JAK inhibitor therapy

  • Institute best practices for transitioning to a clinically appropriate second-line therapy after first-line treatment failure for patients with PV

  • Explain recent clinical efficacy and safety data for second-line treatment regimens for patients with high-risk ET

  • Integrate supportive care plans into practice designed to monitor and manage treatment-related toxicities from new or novel MPN treatments

  • Identify patients with MPNs who are eligible for enrollment on a clinical trial


Clinical Care Options, LLC (CCO) requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose all financial conflicts of interest (COI) they may have with ineligible companies. All relevant COI are thoroughly vetted and mitigated according to CCO policy. CCO is committed to providing its learners with high-quality CME/CE activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of an ineligible company.

The faculty reported the following relevant financial relationships or relationships to products or devices they have with ineligible companies related to the content of this educational activity:

Primary Author

Prithviraj Bose, MD

Associate Professor
Division of Cancer Medicine
Department of Leukemia
The University of Texas MD Anderson Cancer Center
Houston, Texas

Prithviraj Bose, MD: consultant/advisor/speaker: AbbVie, Blueprint, Bristol Myers Squibb, Cogent, CTI, GlaxoSmithKline, Incyte, Karyopharm, Morphosys, Novartis, Pharma Essentia; researcher: Blueprint, Bristol Myers Squibb, Cogent, CTI, Disc Medicine, Incyte, Ionis, Kartos, Morphosys, Telios.

The planners and content peer reviewers from Clinical Care Options, LLC do not have any relevant financial relationships to disclose.

Instructions for Credit

Participation in this self-study activity should be completed in approximately 1 hours. To successfully complete this activity and receive credit, learners must follow these steps during the period from August 21, 2023, through August 22, 2024:

  1. Login or Sign Up for an account by clicking at the top of this page
  2. Read the target audience, learning objectives, and faculty disclosures
  3. View and study the content in its entirety
  4. Submit answers to the post-test questions and evaluation questions online

You must receive a test score of at least 65 and respond to all evaluation questions to receive a certificate. After submitting the evaluation, you may access your online certificate by selecting the certificate link on the confirmation page. Records of all CME/CE activities completed can be found on the "My Certificates" page. There are no costs/fees for this activity.


This program has been made available online.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.


Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.


Joint Accreditation Statement
Joint AccreditationIn support of improving patient care, Clinical Care Options, LLC (CCO) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.


Physician Continuing Medical Education
CCO designates this enduring material for a maximum of 1 AMA PRA Category 1 Credit™ . Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nursing Continuing Professional Development
The maximum number of hours awarded for this Nursing Continuing Professional Development activity is 1 contact hour.

Continuing Pharmacy Education

CCO designates this continuing education activity for 1.0 contact hour (0.10 CEUs) of the Accreditation Council for Pharmacy Education.

Universal Activity Number - JA4008176-0000-23-215-H01-P
Type of Activity: Application

Upon successfully completing the post-test with a score of 65 or better and the activity evaluation form, transcript information will be sent to the NABP CPE monitor Service within 60 days.