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PARADIGM: Panitumumab + mFOLFOX6 vs Bevacizumab + mFOLFOX6 as First-line Treatment for mCRC With Wild-Type RAS

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The phase III PARADIGM trial demonstrated superior overall survival with first-line panitumumab vs bevacizumab in combination with mFOLFOX6 in both the left-sided and overall mCRC populations with WT RAS.

Released: June 09, 2022

Expiration: June 08, 2023

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Supported by educational grants from

AbbVie

AstraZeneca

Bristol Myers Squibb

Daiichi Sankyo, Inc.

Gilead Sciences, Inc.

GlaxoSmithKline

Jazz Pharmaceuticals, Inc.

Merck Sharp & Dohme Corp.

Novartis Pharmaceuticals Corporation

Seagen and Genmab