Faculty

Tal Oren, MD, PhD

Hematopathologist
Stamford Hospital
Stamford, Connecticut

Alexa J. Siddon, MD

Associate Professor, Laboratory Medicine and Pathology
Hematopathology Fellowship Director
Yale School of Medicine
New Haven, Connecticut

Cecilia Yeung, MD

Associate Professor
Clinical Research Division
Fred Hutchinson Cancer Center
University of Washington
Seattle, Washington

Provided by

Provided by Clinical Care Options, LLC

Supporters

Supported by an educational grant from

Bristol Myers Squibb

Target Audience

This educational program is intended for pathologists, hematopathologists, hematologists, hematologists/oncologists, and other healthcare professionals involved in precision care of MDS.

Learning Objectives

Upon completion of this activity, participants should be able to:

Formulate an actionable diagnostic workup plan for MDS with ring sideroblasts and MDS/MPN with ring sideroblasts and thrombocytosis considering ring sideroblast quantification and evaluation, current guidelines, and clinical evidence
Ascertain the clinical rationale for SF3B1 testing combined with ring sideroblast assessment in the diagnosis of MDS based on the currently available data, guidelines, and expert recommendations
Identify technologies available to pathologists that can be used to test for SF3B1 mutations
Integrate into practice adequate sampling and sampling types for the accurate diagnosis of MDS with ring sideroblasts and MDS/MPN with ring sideroblasts and thrombocytosis to guide treatment decisions

Disclosure

Clinical Care Options, LLC (CCO) requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose all financial conflicts of interest (COI) they may have with ineligible companies. All relevant COI are thoroughly vetted and mitigated according to CCO policy. CCO is committed to providing its learners with high-quality CME/CE activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of an ineligible company.

The faculty reported the following relevant financial relationships or relationships to products or devices they have with ineligible companies related to the content of this educational activity:

Faculty Disclosure

Primary Author

Tal Oren, MD, PhD

Hematopathologist
Stamford Hospital
Stamford, Connecticut

Tal Oren, MD, PhD, has no relevant financial relationships to disclose.

Alexa J. Siddon, MD

Associate Professor, Laboratory Medicine and Pathology
Hematopathology Fellowship Director
Yale School of Medicine
New Haven, Connecticut

Alexa J. Siddon, MD, has no relevant financial relationships to disclose.

Cecilia Yeung, MD

Associate Professor
Clinical Research Division
Fred Hutchinson Cancer Center
University of Washington
Seattle, Washington

Cecilia Yeung, MD: consultant/advisor/speaker: Twinstrands; researcher: OBI, Sensei.

The planners and content peer reviewers from Clinical Care Options, LLC do not have any relevant financial relationships to disclose.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Disclaimer

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Accreditation

Joint Accreditation Statement

In support of improving patient care, Clinical Care Options, LLC (CCO) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physician Continuing Medical Education

Credit Designation

CCO designates this enduring material for a maximum of 1.0 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to maximum of 1.0 Lifelong Learning point in the American Board of Pathologyâ€™s Maintenance of Certification (MOC) Program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity providerâ€™s responsibility to submit learner completion information to ACCME for the purpose of granting ABPath Continuing Certification (formerly Maintenance of Certification or MOC) credit.

American Board of Internal Medicine Maintenance of Certification

Successful completion of this activity, which includes participation in the evaluation component, enables the participant to earn up to maximum of 1.0 Medical Knowledge MOC point in the American Board of Internal Medicine's (ABIM) Maintenance of Certification (MOC) program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider's responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

American Board of Pathology Continuing Certification

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to maximum of 1.0 Lifelong Learning point in the American Board of Pathology’s Maintenance of Certification (MOC) Program. Participants will earn MOC points equivalent to the amount of CME credits claimed for the activity. It is the CME activity provider’s responsibility to submit learner completion information to ACCME for the purpose of granting ABPath Continuing Certification (formerly Maintenance of Certification or MOC) credit.

Additional Information

Participation in this self-study activity should be completed in approximately 1 hours. To successfully complete this activity and receive credit, participants must follow these steps during the period from November 29, 2022, through November 28, 2023:

1. Register online at http://www.clinicaloptions.com.
2. Read the target audience, learning objectives, and faculty disclosures.
3. Study the educational activity online or printed out.
4. Submit answers to the posttest questions and evaluation questions online.

You must receive a test score of at least 65% and respond to all evaluation questions to receive a certificate. After submitting the evaluation, you may access your online certificate by selecting the certificate link on the posttest confirmation page. Records of all CME/CE activities completed can be found on the "CME/CE Manager" page. There are no costs/fees for this activity.

Program Medium

This program has been made available online.

Goal

The goal of this activity is to improve the knowledge, confidence, competence, and performance of learners to accurately diagnose and provide evidence-based treatment strategies for patients with MDS-RS and MDS/MPN-RS-T.

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