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Pooled Analysis of Impact of TP53 Mutations on Efficacy of Venetoclax + Azacitidine in Patients With AML and Poor-Risk Cytogenetics

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In older/unfit patients with AML and poor-risk cytogenetics, frontline treatment with venetoclax plus azacitidine improved DoR and OS vs Aza in wild-type but not mutated TP53.

Released: December 17, 2021

Expiration: December 16, 2022

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Merck Sharp & Dohme Corp.

Novartis Pharmaceuticals Corporation