Audio Recap: PrEP Initiation
PrEP Initiation: Answering the Questions

Released: July 13, 2023

Linda-Gail Bekker
Linda-Gail Bekker, MBChB, DTMH, DCH, FCP(SA), PhD
Meredith E. Clement
Meredith E. Clement, MD

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In this episode, Linda-Gail Bekker, MBChB, DTM&H, DCH, FCP(SA), PhD, and Meredith Clement, MD, discuss PrEP initiation, including:

  • The importance of taking a sexual history and getting to know your patient
  • Recommendations for who should be considered for PrEP
  • Practicalities of PrEP initiation including laboratory assessments, interview and physical exam, evaluating concomitant medications, counseling, and prescribing
  • Summary of PrEP eligibility by regimen
  • Review of the clinical trial and real-world data for each PrEP modality
  • The likelihood of cross-resistance between PrEP options and ART options if someone were to become infected with HIV while receiving PrEP
  • Time to effective concentrations of PrEP after initiation
  • Whether there are data for on-demand dosing of FTC/TAF
  • Recommendations for FTC/TDF on demand for heterosexual cisgender men
  • Individualizing PrEP for each person to increase the likelihood of adherence, persistence, and efficacy
  • Recommendations for the use of LA CAB for PrEP during pregnancy and in people of childbearing potential
  • STI and point-of-care testing for people receiving PrEP
  • The possibility of implantable PrEP in the future