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Addressing Challenges in Long-Term Prophylaxis for Hereditary Angioedema

Clinical Thought

Read an expert’s perspective on addressing challenges and serving unmet needs in using long-term prophylaxis for hereditary angioedema, and strategies for incorporating emerging therapies into practice.

Physician Assistants/Physician Associates: 0.25 AAPA Category 1 CME credit

Nurses: 0.25 Nursing contact hour

Physicians: maximum of 0.25 AMA PRA Category 1 Credit

Released: June 27, 2024

Expiration: June 26, 2025



Jonathan A. Bernstein

Jonathan A. Bernstein, MD

Professor of Medicine
University of Cincinnati College of Medicine
Department of Internal Medicine
Division of Rheumatology, Allergy and Immunology
Partner Bernstein Allergy Group and Bernstein Clinical Research Center
Cincinnati, Ohio

Provided by

Provided by Clinical Care Options, LLC

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Supported by an educational grant from Ionis Pharmaceuticals, Inc.

Ionis Pharmaceuticals, Inc.

Target Audience

This program is intended for allergy/immunology healthcare professionals who manage patients with HAE, including physicians, residents, fellows, nurse practitioners, and physician associates.

Program Learning Goal

The goal of this program is to improve the knowledge and competence of learners in effort to optimize treatment for patients with Hereditary Angioneurotic Edema (HAE).

Learning Objectives

Upon completion of this activity, participants should be able to: 

  • Detail unmet needs of patients living with HAE


Clinical Care Options, LLC (CCO) requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose all financial conflicts of interest (COI) they may have with ineligible companies. All relevant COI are thoroughly vetted and mitigated according to CCO policy. CCO is committed to providing its learners with high-quality CME/CE activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of an ineligible company.

The faculty reported the following relevant financial relationships or relationships to products or devices they have with ineligible companies related to the content of this educational activity:

Primary Author

Jonathan A. Bernstein, MD

Professor of Medicine
University of Cincinnati College of Medicine
Department of Internal Medicine
Division of Rheumatology, Allergy and Immunology
Partner Bernstein Allergy Group and Bernstein Clinical Research Center
Cincinnati, Ohio

Jonathan A. Bernstein, MD: researcher: Allakos, Amgen, BioCryst, BioMarin, Celldex, CSL Behring, Escient, Genentech, Intellia, Ionis, Jasper, Kalvista, Novartis, Pharming, Takeda/Shire.

The planners and content peer reviewers from Clinical Care Options, LLC have no relevant financial relationships to disclose except Katherine Prince, FNP and Amanda Michaud, DMSc, PA-C, AE-C as noted below:​

Katherine Prince, FNPconsultant/advisor/speaker: CorEvitas LLC.​

Amanda Michaud, DMSc, PA-C, AE-C: consultant/advisor/speaker: Dermavant, Novartis, Pfizer, Regeneron.

Instructions for Credit

Participation in this self-study activity should be completed in approximately 0.25 hours. To successfully complete this activity and receive credit, participants must follow these steps during the period from June 27, 2024, through June 26, 2025:

  1. Login or Sign Up for an account by clicking at the top of this page.
  2. Read the target audience, learning objectives, and faculty disclosures.
  3. View and study the content in its entirety.
  4. Submit answers to the posttest questions and evaluation questions online.

You must receive a test score of at least 65 and respond to all evaluation questions to receive a certificate. After submitting the evaluation, you may access your online certificate by selecting the certificate link on the confirmation page. Records of all CME/CE activities completed can be found on the "My Certificates" page. There are no costs/fees for this activity.


This program has been made available online.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.


Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.


Joint Accreditation Statement

In support of improving patient care, Clinical Care Options, LLC (CCO) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physician Continuing Medical Education

CCO designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nursing Continuing Professional Development

The maximum number of hours awarded for this Nursing Continuing Professional Development activity is 0.25 contact hours.

Physician Associate Continuing Medical Education

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Clinical Care Options, LLC has been authorized by the American Academy of PAs (AAPA) to award AAPA Category 1 CME credit for activities planned in accordance with AAPA CME Criteria. This activity is designated for 0.25 AAPA Category 1 CME credits. Approval is valid until June 26, 2025. PAs should only claim credit commensurate with the extent of their participation.

CME Passport

The CME credits that physicians earn from this activity will be submitted to ACCME's CME Passport, a free, centralized web application where you can create a personalized account to view, track, and generate transcripts of your reported CME credit. Visit to create your account.