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CE / CME

Defining Nonresponse to PBC Treatment: Curbside Consults

Video

When should you move from first-line to second-line treatment for primary biliary cholangitis (PBC)? Learn from expert faculty as they discuss how and when to measure treatment response, evidence-based goals of therapy, and how to select second-line treatment.

Nurses: 0.25 Nursing contact hour

Physicians: Maximum of 0.25 AMA PRA Category 1 Credit

Released: February 03, 2025

Expiration: February 02, 2026

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Provided by Clinical Care Options, LLC

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Supporters

Supported by educational grants from Gilead Sciences, Inc. and Ipsen Biopharmaceuticals, Inc

Gilead Sciences, Inc.

Ipsen Biopharmaceuticals Inc

Target Audience

This activity is intended for physicians, including hepatologists and gastroenterologists, nurse practitioners, nurses, and other healthcare professionals involved in the care of patients with PBC.

Program Learning Goal

The goal of this activity is to improve learners’ knowledge and competence in managing complex PBC cases, including monitoring, adjustment of therapy, symptom management, and integration of new agents into therapy plans.

Learning Objectives

Upon completion of this activity, participants should be able to: 

  • Develop comprehensive treatment plans for patients with PBC, including therapy selection and monitoring parameters

  • Adjust PBC therapy based on biochemical response, symptom burden, and tolerance 

  • Incorporate new PBC agents into therapeutic plans for individual patients 

Disclosure

Clinical Care Options, LLC (CCO) requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose all financial conflicts of interest (COI) they may have with ineligible companies. All relevant COI are thoroughly vetted and mitigated according to CCO policy. CCO is committed to providing its learners with high-quality CME/CE activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of an ineligible company.

The faculty reported the following relevant financial relationships or relationships to products or devices they have with ineligible companies related to the content of this educational activity:

Primary Author

Alan Bonder, MD, AGAF

Associate Professor of Medicine
Medical Director of Liver Transplant
Department of Gastroenterology
Beth Israel Deaconess Medical Center
Harvard Medical School
Boston, Massachusetts

Alan Bonder, MD, AGAF: consultant/advisor/speaker: Chemomab, CymaBay/Gilead, GlaxoSmithKline, Intercept, Ipsen; researcher: CymaBay/Gilead, Intercept, Ipsen, Mirium.

Aparna Goel, MD

Associate Clinical Professor of Medicine
Division of Gastroenterology and Hepatology
Stanford University
Palo Alto, California

Aparna Goel, MD, has no relevant financial relationships to disclose.

The planners and content peer reviewers from Clinical Care Options, LLC do not have any relevant financial relationships to disclose.

Instructions for Credit

Participation in this self-study activity should be completed in approximately 0.25 hours. To successfully complete this activity and receive credit, participants must follow these steps during the period from February 03, 2025, through February 02, 2026:

  1. Login or Sign Up for an account by clicking at the top of this page.

  2. Read the target audience, learning objectives, and faculty disclosures.

  3. View and study the content in its entirety.

  4. Submit answers to the posttest questions and evaluation questions online.

You must receive a test score of at least 65 and respond to all evaluation questions to receive a certificate. After submitting the evaluation, you may access your online certificate by selecting the certificate link on the confirmation page. Records of all CME/CE activities completed can be found on the "My Certificates" page. There are no costs/fees for this activity.

Format

This program has been made available online.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Disclaimer

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Accreditation

Joint Accreditation Statement

In support of improving patient care, Clinical Care Options, LLC (CCO) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physician Continuing Medical Education

CCO designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Nursing Continuing Professional Development

The maximum number of hours awarded for this Nursing Continuing Professional Development activity is 0.25 contact hours.

CME Passport

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The CME credits that physicians earn from this activity will be submitted to ACCME's CME Passport, a free, centralized web application where you can create a personalized account to view, track, and generate transcripts of your reported CME credit. Visit www.cmepassport.org to create your account.