CML IDST
Expert Guidance on Monitoring Response to BCR-ABL1 Inhibitors in CML: An Interactive Decision Support Tool

Released: January 07, 2025

Expiration: January 06, 2026

Instructions

This Interactive Decision Support Tool provides recommendations from 5 renowned experts for the clinical management of patients with CML in chronic phase based on specific response characteristics to first-line BCR-ABL1 inhibitor therapy that you enter in the tool. It is recommended that you have as much information as possible available before you begin.

You will be prompted to provide specific information about your patient, including duration of BCR-ABL1 inhibitor therapy, BCR-ABL1IS transcript levels by quantitative reverse-transcriptase polymerase chain reaction (RT-PCR), and any quality-of-life and adverse event issues the patient is experiencing as a result of therapy.

Click on your selections. Your choices can be changed at any time simply by reviewing your saved answers, clicking on the [Change] link by your current answer, and selecting a new choice.

Additional information on each variable/characteristic and why it is important for making management decisions is available by clicking on the [i] icon after each selection.

When all patient characteristics are entered, you will be asked to select the management option you are currently planning. Once that information is entered, you can click on Submit Patient Case to view the expert recommendations.

After reviewing your case-specific recommendations, you will be asked brief questions about how the recommendations influenced your decision-making. You will then be able to enter a new case scenario by clicking the Start New Case button.

Additional sections appear in the table of contents menu to provide more information about this tool: About This Tool, Instructions, and References.

When viewing the tool on the CCO website, you will also be able to print/download the recommendations along with a summary of the patient characteristics and selected therapy you entered by clicking the Case Summary button.

Note: The current tool was developed between October and December 2024 and reflects the expert recommendations at that time.

Access to and use of this Interactive Decision Support Tool titled, “Expert Guidance on Monitoring Response to BCR-ABL1 Inhibitors in CML: An Interactive Decision Support Tool” is provided subject to the following terms and conditions. PLEASE READ THESE TERMS CAREFULLY.

This Interactive Decision Support Tool is designed to educate healthcare professionals on the optimal management of patients with CML in chronic phase using TKIs. The information provided is based on guideline recommendations and expert guidance of Daniel J. DeAngelo, MD, PhD; Michael J. Mauro, MD; Neil P. Shah, MD, PhD; B. Douglas Smith, MD; and Tiffany N. Tanaka, MD.

The material published by Clinical Care Options reflects the views of the reviewers or authors of the CCO material, not those of Clinical Care Options, LLC, the accredited provider, or the companies providing educational grants. The materials may discuss uses and dosages for therapeutic products that have not been approved by the FDA. A qualified healthcare professional should be consulted before using any therapeutic product discussed. Readers should verify all information and data before treating patients or using any therapies described in these materials.

Although the information contained in the “Expert Guidance on Monitoring Response to BCR-ABL1 Inhibitors in CML: An Interactive Decision Support Tool” has been produced and processed from sources believed to be reliable, no warranty, expressed or implied, is made regarding the accuracy, adequacy, completeness, legality, reliability, or usefulness of any information. This disclaimer applies to both the isolated and aggregate uses of the information. Clinical Care Options provides this information on an as-is basis. This disclaimer applies to all material published by Clinical Care Options including but not limited to medical information or opinions. All warranties of any kind, expressed or implied, including but not limited to the implied warranties of merchantability, fitness for a particular purpose, freedom from contamination by computer viruses, and noninfringement of proprietary rights are disclaimed.

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