Faculty

Sameh Gaballa, MD

Associate Member
Lymphoma Division
Department of Malignant Hematology
Specialized Oncology Non-Cellular Immunotherapy Comprehensive (SONIC) Service Co-Director
Moffitt Cancer Center
Associate Professor, Oncologic Sciences
University of South Florida
Tampa, Florida

Nitin Jain, MD

Professor, Department of Leukemia
Director, Leukemia CAR-T Program
The University of Texas MD Anderson Cancer Center
Houston, Texas

Provided by

Provided by Clinical Care Options, LLC.

Supporters

Lilly

Target Audience

This educational activity is intended for hematologists, medical oncologists, and other healthcare professionals who care for patients with chronic lymphocytic leukemia / small lymphocytic lymphoma.

Program Learning Goal

This activity's goal is to improve learners' knowledge and competence in treating patients with chronic lymphocytic leukemia / small lymphocytic lymphoma who are receiving or are eligible to receive treatment with BTK inhibitor-based therapy.

Learning Objectives

Upon completion of this activity, participants should be able to:

Incorporate CLL/SLL molecular pathogenesis of available BTK inhibitors, as well as mechanisms of resistance and tolerance of prior therapy when developing individualized treatment approaches for patients
Select optimal guideline-recommended BTK inhibitor treatments for patients with CLL/SLL across the disease spectrum, based on current evidence, guidelines, expert guidance, and patient goals and preferences
Integrate current evidence on evolving BTK inhibitor approaches into treatment planning for patients with CLL/SLL across the disease spectrum
Identify and manage BTK inhibitor–associated adverse events in patients with CLL/SLL and educate them on when to call their care team

Disclosure

Clinical Care Options, LLC (CCO) requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose all financial conflicts of interest (COI) they may have with ineligible companies. All relevant COI are thoroughly vetted and mitigated according to CCO policy. CCO is committed to providing its learners with high-quality CME/CE activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of an ineligible company.

The faculty reported the following relevant financial relationships or relationships to products or devices they have with ineligible companies related to the content of this educational activity:

Primary Author

Sameh Gaballa, MD: consultant/advisor/speaker: AbbVie, Adaptive Biotechnologies, ADC Therapeutics, AstraZeneca, BeOne, Incyte, Ipsen, Lilly, Regeneron.

Nitin Jain, MD: advisor/honoraria: AbbVie, Adaptive, AstraZeneca, Autolus, BeOne, Bristol Myers Squibb, Cellectis, Genentech, Janssen, Kite/Gilead, Lilly, Novalgen, Nurix, Pharmacyclics, SERB Pharma; research: AbbVie, Adaptive, ADC Therapeutics, Ascentage, AstraZeneca, BeOne, Bioheng, Bristol Myers Squibb, Carna, Cellectis, Fate, Genentech, Kisoji, Kite/Gilead, Lilly, Mingsight, Newave, Novartis, Precision Biosciences, Pharmacyclics, Sana, Takeda, Triarm, Ubix.

The planners and content peer reviewers from Clinical Care Options, LLC do not have any relevant financial relationships to disclose.

Instructions for Credit

Participation in this self-study activity should be completed in approximately 1 hour. To successfully complete this activity and receive credit, participants must follow these steps during the period from November 11, 2025, through May 10, 2026:

Login or Sign Up for an account by clicking at the top of this page.
Read the target audience, learning objectives, and faculty disclosures.
View and study the content in its entirety.
Submit answers to the posttest questions and evaluation questions online.

You must receive a test score of at least 65 and respond to all evaluation questions to receive a certificate. After submitting the evaluation, you may access your online certificate by selecting the certificate link on the confirmation page. Records of all CME/CE activities completed can be found on the "My Certificates" page. There are no costs/fees for this activity.

Format

This program has been made available online.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Disclaimer

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Accreditation

Joint Accreditation Statement

In support of improving patient care, Clinical Care Options, LLC (CCO) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physician Continuing Medical Education

CCO designates this enduring material for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

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The CME credits that physicians earn from this activity will be submitted to ACCME's CME Passport, a free, centralized web application where you can create a personalized account to view, track, and generate transcripts of your reported CME credit. Visit www.cmepassport.org to create your account.

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Conference to Clinic—Advancing Integration of BTK Inhibitors in CLL/SLL Treatment: Expert Insights on Evolving Approaches to Optimize Care

Video