Managing Carbapenem-Resistant Gram-Negative infection

CE / CME

Rise of the Resistance: Challenging Carbapenem-Resistant Gram-Negative Infections

Nurses: 1.50 Nursing contact hours

Pharmacists: 1.50 contact hours (0.15 CEUs)

Physicians: maximum of 1.50 AMA PRA Category 1 Credits

Released: November 04, 2024

Expiration: November 03, 2025

Marguerite L. Monogue
Marguerite L. Monogue, PharmD, BCIDP
Michael J. Satlin
Michael J. Satlin, MD, MS, FIDSA

Pretest

Progress
1 2 3
Course Completed
Please answer the questions below.
1.

Patient Case 1



  • 70-yr-old with recent surgical repair of an esophageal diverticulum c/b pneumomediastinum from esophageal perforation (managed without surgery)

  • Now readmitted after 3 days with new fever and hematemesis, immediately sent to OR for surgical intervention

  • 12-hr later, anaerobic blood bottles flag positive

    • Gram stain: GNR

    • Molecular testing: E. coli with NDM carbapenem resistance gene



If following current IDSA guidance, which is recommended for this patient?

2.

Patient Case 2



  • 62-yr-old with unresectable intrahepatic cholangiocarcinoma with recurrent biliary sepsis and recent P. aeruginosa bacteremia

  • Readmitted 1 mo later with hemoperitoneum with large volume ascites and recurrent P. aeruginosa bacteremia


If following current IDSA guidance, which regimen is preferred for this patient?

3.

If following current IDSA guidance, which regimen is recommended for S. maltophilia infections?