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Utilizing PK/PD Modeling to Optimize On-Demand TDF/FTC PrEP Dosing for Women

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Dosing simulations for on-demand pre-exposure prophylaxis (PrEP) with TDF/FTC were evaluated for women using pharmacokinetic and pharmacodynamic modeling of female genital tract concentrations. All 4-day dosing regimens allowed for more than 80% of simulated profiles to surpass predefined pharmacokinetic/pharmacodynamic targets 7 days after sex.

Released: March 14, 2025

Expiration: September 13, 2025

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Provided by Clinical Care Options, LLC

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Supported by educational grants from Gilead Sciences, Inc., Merck & Co., Inc., Rahway, NJ, USA, and ViiV Healthcare.

Gilead Sciences, Inc.

Merck & Co., Inc., Rahway, NJ, USA

ViiV Healthcare