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Less Is More: Managing Polypharmacy for People Living With HIV and Multimorbidity

Clinical Thought

Even for healthcare professionals who are familiar with complex medication regimens, managing polypharmacy for people living with HIV and multimorbidity can be overwhelming. Read on to learn how I approach medication de-escalation and simplification by breaking it down into manageable steps. 

Released: August 13, 2025

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Jointly provided by ProCE, LLC, Clinical Care Options, LLC and American Academy of HIV Medicine (AAHIVM)

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Supporters

Supported by an educational grant from Gilead Sciences, Inc.

Gilead Sciences, Inc.

Learning Objectives

Upon completion of this activity, participants should be able to: 

  • Evaluate the appropriate use of ART regimens based on guideline recommendations and patient-specific factors such as patient preferences, presence of renal or hepatic impairment, concomitant medications, and underlying comorbidities

  • Advise on innovative ART strategies to individualize HIV treatment, including complex clinical cases such as in the setting of polypharmacy, multimorbidity, and ARV resistance

  • Identify candidates and appropriate PrEP regimens for individual patients based on available agents and current evidence

  • Employ practical strategies within different pharmacy practice settings to overcome barriers to increased PrEP use among those for whom it is recommended, especially underserved patient subpopulations

  • Develop a comprehensive approach to HIV prevention involving delivery of tailored PrEP regimens and incorporation of other sexual health services

Disclosure

Primary Author

Alexis E. Horace, PharmD, BCACP, has no relevant financial relationships to disclose.