eCase - ASCO 2023 GI Cancers

Introduction

In this activity, Christopher H. Lieu, MD, and Rachna T. Shroff, MD, MS, FASCO, review key gastrointestinal (GI) cancer studies presented at the 2023 American Society of Clinical Oncology (ASCO) Annual Meeting, focusing on new data surrounding the treatment of colorectal, hepatobiliary, and pancreatic cancers.

Please note that the slide thumbnails in this activity link to brief PowerPoint slidesets, each focused on the specific study or topic of interest. These slidesets may be downloaded by clicking on any of the thumbnails within the activity.

Clinical Care Options plans to measure the educational impact of this activity. Some questions will be asked twice: once at the beginning of the activity, and once again after the discussion that informs the best choice. Your responses will be aggregated for analysis, and your specific responses will not be shared.

Before continuing with this educational activity, please take a moment to answer the following questions.

If you are a practicing healthcare professional, how many patients with GI cancers do you provide care for in a typical month?

A.
1-4
B.
5-10
C.
11-15
D.
16-20
E.
>20
F.
Not applicable

A patient with T3 node-negative rectal cancer will receive total mesorectal excision. Based on data from the PROSPECT trial presented at ASCO 2023, how would you counsel this patient regarding neoadjuvant therapy with FOLFOX plus selective chemoradiation vs chemoradiation alone?

A.
Noninferior disease-free survival (DFS) outcomes; statistically similar quality of life (QoL) findings
B.
Noninferior DFS outcomes; QoL was significantly better with chemoradiation
C.
Chemoradiation was superior to FOLFOX for DFS; statistically similar QoL findings
D.
Chemoradiation was superior to FOLFOX for DFS; QoL was significantly better with chemoradiation
E.
Uncertain

Which of the following was reported at ASCO 2023 from the NORPACT-1 phase II trial of upfront surgery vs neoadjuvant FOLFIRINOX followed by surgery for patients with resectable pancreatic head cancers?

A.
Improved median overall survival (OS), R0/N0 resection rates with neoadjuvant FOLFIRINOX
B.
Improved median OS with FOLFIRINOX, similar R0/N0 resection rates between strategies
C.
Similar median OS between strategies, improved R0/N0 resection rates with neoadjuvant FOLFIRINOX
D.
Similar median OS, R0/N0 resection rates with both strategies

Based on data from a phase II basket study presented at ASCO 2023, patients with previously treated advanced biliary tract cancer (BTC) and which of the following HER2 alterations derived benefit from tucatinib plus trastuzumab?

A.
HER2 mutations
B.
HER2 overexpression/amplification
C.
Both HER2 mutations and overexpression/amplification
D.
Any HER2 expression level

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Key Studies in Gastrointestinal Cancers: Independent Conference Coverage of the 2023 ASCO Annual Meeting

Christopher H. Lieu, MD

Rachna Shroff, MD, MS, FASCO

Activity

Introduction

If you are a practicing healthcare professional, how many patients with GI cancers do you provide care for in a typical month?

A patient with T3 node-negative rectal cancer will receive total mesorectal excision. Based on data from the PROSPECT trial presented at ASCO 2023, how would you counsel this patient regarding neoadjuvant therapy with FOLFOX plus selective chemoradiation vs chemoradiation alone?

Which of the following was reported at ASCO 2023 from the NORPACT-1 phase II trial of upfront surgery vs neoadjuvant FOLFIRINOX followed by surgery for patients with resectable pancreatic head cancers?

Based on data from a phase II basket study presented at ASCO 2023, patients with previously treated advanced biliary tract cancer (BTC) and which of the following HER2 alterations derived benefit from tucatinib plus trastuzumab?