eCase - ASCO 2024 Breast Cancer

Introduction

In this activity, Sara Hurvitz, MD, FACP, and Kevin Kalinsky, MD, MS, FASCO, review key studies in breast cancer presented at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting, with a focus on the clinical implications of new data.

Please note that the slide thumbnails in this activity link to PowerPoint slidesets, each focused on the specific study or topic of interest. These slidesets may be downloaded by clicking on any of the thumbnails within the activity.

Clinical Care Options plans to measure the educational impact of this activity. Some questions will be asked twice: once at the beginning of the activity, and once again after the discussion that informs the best choice. Your responses will be aggregated for analysis, and your specific responses will not be shared.

Before continuing with this educational activity, please take a moment to answer the following questions.

How many people with breast cancer do you provide care for in a typical week?

A.
1-4
B.
5-10
C.
11-15
D.
16-20
E.
>20
F.
Not applicable

Which of the following findings was reported from the DESTINY-Breast06 trial with trastuzumab deruxtecan (T-DXd) vs physician’s choice of chemotherapy in patients with previously treated hormone receptor (HR)-positive/HER2-low or HER2-ultralow metastatic breast cancer (MBC) who had not previously received chemotherapy for MBC?

A.
Improvement of progression-free survival (PFS) in HER2-low disease only
B.
Improvement of PFS in both HER2-low and HER2-ultralow disease
C.
A similar objective response rate (ORR) in HER2-low disease
D.
A lower ORR in HER2-ultralow disease

In the postMONARCH phase III trial, patients with HR-positive/HER2-negative MBC and progression after 1 year of first-line therapy with an aromatase inhibitor (AI) plus which of the following CDK4/6 inhibitors were most likely to benefit from a second-line therapy of abemaciclib plus fulvestrant?

A.
Palbociclib
B.
Ribociclib
C.
Palbociclib and ribociclib showed equivalent benefit
D.
All of the approved CDK4/6 inhibitors showed equivalent benefit

Based on a subset analysis from RxPONDER, which of the following serum hormone levels would you order to help guide your adjuvant therapy recommendations for a 48-year-old premenopausal woman with newly diagnosed HR-positive/HER2-negative breast cancer?

A.
Anti-Müllerian hormone (AMH)
B.
Estradiol
C.
Follicle-stimulating hormone (FSH)
D.
Luteinizing hormone (LH)

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Key Studies in Breast Cancer: Independent Conference Coverage of the 2024 ASCO Annual Meeting

Sara A. Hurvitz, MD, FACP

Kevin Kalinsky, MD, MS

Activity

Introduction

How many people with breast cancer do you provide care for in a typical week?

In the postMONARCH phase III trial, patients with HR-positive/HER2-negative MBC and progression after 1 year of first-line therapy with an aromatase inhibitor (AI) plus which of the following CDK4/6 inhibitors were most likely to benefit from a second-line therapy of abemaciclib plus fulvestrant?

Based on a subset analysis from RxPONDER, which of the following serum hormone levels would you order to help guide your adjuvant therapy recommendations for a 48-year-old premenopausal woman with newly diagnosed HR-positive/HER2-negative breast cancer?