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Myelofibrosis Expert Roundtable: State-of-the-Art Clinical Advances and Therapeutic Strategies From JAK Inhibition Into the Future

Video

On-demand webcast of expert faculty presentation and case discussion on current and emerging data for treating patients with myelofibrosis using JAK inhibitors, from CCO’s expert roundtable symposium at ASCO 2024. 

Physicians: Maximum of 1.50 AMA PRA Category 1 Credits

Released: June 18, 2024

Expiration: June 17, 2025

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Faculty

Prithviraj Bose

Prithviraj Bose, MD

Professor
Department of Leukemia
Division of Cancer Medicine
University of Texas MD Anderson Cancer Center
Houston, Texas

Lucia Masarova

Lucia Masarova, MD

Assistant Professor
Leukemia Department
Division of Cancer Medicine
MD Anderson Cancer Center
Houston, Texas

Raajit K. Rampal

Raajit K. Rampal, MD, PhD

Associate Member
Director, MPN and Rare Hematologic Malignancies Program
Director, Center for Hematologic Malignancies
Memorial Sloan Kettering Cancer Center
New York, New York

Provided by

Provided by Clinical Care Options, LLC

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Supporters

Supported by an educational grant from GlaxoSmithKline.

GlaxoSmithKline

Target Audience

This program is intended for medical oncologists and other healthcare professionals who treat patients with myelofibrosis.

Program Learning Goal

The goal of this program is to improve the knowledge and competence of learners in effort to optimize treatment for patients with Myelofibrosis.

Learning Objectives

Upon completion of this activity, participants should be able to: 

  • Select the optimal JAK inhibitor or JAK inhibitor‒based combination considering disease and patient-specific factors, available data, and expert recommendations

  • Develop evidence-based second-line therapeutic strategies for patients with myelofibrosis who are relapsed, refractory, or intolerant to prior JAK inhibitor therapy

  • Plan therapeutic strategies for patients with myelofibrosis and moderate to severe anemia

  • Evaluate available clinical data and expert perspectives on agents and combination regimens that improve constitutional symptoms, splenomegaly, and cytopenias associated with myelofibrosis

  • Explain new data on emerging agents to educate colleagues and counsel patients regarding ongoing trial opportunities in myelofibrosis

Disclosure

Clinical Care Options, LLC (CCO) requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose all financial conflicts of interest (COI) they may have with ineligible companies. All relevant COI are thoroughly vetted and mitigated according to CCO policy. CCO is committed to providing its learners with high-quality CME/CE activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of an ineligible company.

The faculty reported the following relevant financial relationships or relationships to products or devices they have with ineligible companies related to the content of this educational activity:

Primary Author

Prithviraj Bose, MD

Professor
Department of Leukemia
Division of Cancer Medicine
University of Texas MD Anderson Cancer Center
Houston, Texas

Prithviraj Bose, MD: consultant/advisor/speaker: AbbVie, Blueprint, Bristol Myers Squibb, Cogent, CTI, Disc, GlaxoSmithKline, Incyte, Ionis, Jubilant, Karyopharm, Morphic, MorphoSys, Novartis, PharmaEssentia, Sumitomo; researcher: Blueprint, Bristol Myers Squibb, Cogent, CTI, Disc, Geron, Incyte, Ionis, Janssen, Kartos, Karyopharm, MorphoSys, Sumitomo, Telios.

Lucia Masarova, MD

Assistant Professor
Leukemia Department
Division of Cancer Medicine
MD Anderson Cancer Center
Houston, Texas

Lucia Masarova, MD: consultant/advisor/speaker: Cogent, GlaxoSmithKline, MorphoSys, PharmaEssentia.

Raajit K. Rampal, MD, PhD

Associate Member
Director, MPN and Rare Hematologic Malignancies Program
Director, Center for Hematologic Malignancies
Memorial Sloan Kettering Cancer Center
New York, New York

Raajit K. Rampal, MD, PhD: consultant/advisor/speaker: AbbVie, Blueprint, Celgene/Bristol Myers Squibb, Cogent, Constellation/Morphosys, CTI, Galecto, Incyte, Jubliant, Kartos, Karyopharm, Pharmaessentia, Sierra Oncology/GlaxoSmithKline, Protagonist, Servier, Stemline, Sumitomo Dainippon, Zentalis; researcher: Constellation, Incyte, Ryvu, Stemline Therapeutics, Zentalis.

The planners and content peer reviewers from Clinical Care Options, LLC do not have any relevant financial relationships to disclose.

Instructions for Credit

Participation in this self-study activity should be completed in approximately 1.5 hours. To successfully complete this activity and receive credit, participants must follow these steps during the period from June 18, 2024, through June 17, 2025:

  1. Login or Sign Up for an account by clicking at the top of this page.
  2. Read the target audience, learning objectives, and faculty disclosures.
  3. View and study the content in its entirety.
  4. Submit answers to the posttest questions and evaluation questions online.

You must receive a test score of at least 65 and respond to all evaluation questions to receive a certificate. After submitting the evaluation, you may access your online certificate by selecting the certificate link on the confirmation page. Records of all CME/CE activities completed can be found on the "My Certificates" page. There are no costs/fees for this activity.

Format

This program has been made available online.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Disclaimer

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Accreditation

Joint Accreditation Statement

In support of improving patient care, Clinical Care Options, LLC (CCO) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physician Continuing Medical Education

CCO designates this enduring material for a maximum of 1.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

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The CME credits that physicians earn from this activity will be submitted to ACCME's CME Passport, a free, centralized web application where you can create a personalized account to view, track, and generate transcripts of your reported CME credit. Visit www.cmepassport.org to create your account.