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Optimizing Asparaginase Therapy Across the Age Spectrum in ALL

Clinical Thought

This expert commentary highlights evidence-based strategies for optimizing asparaginase therapy in patients with ALL of different ages from pediatric to adult, including how to manage hypersensitivity reactions, silent inactivation, and age-related toxicities.

Released: July 31, 2025

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Provided by Clinical Care Options, LLC

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Supporters

Supported by an educational grant from Jazz Pharmaceuticals, Inc.

Jazz Pharmaceuticals, Inc.

Disclosure

Primary Author

Keith J. August, MD, MS: consultant/advisor/speaker: Jazz.

Emily Curran, MD: consultant/advisor/speaker: Autolus, Jazz, Servier.

Van Huynh, MD: consultant/advisor/speaker: Amgen; other (grant funding): Jazz, Servier.