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BTK Inhibitor Therapy in CLL

CE

Optimizing BTK Inhibitor Therapy in CLL: Updates and Strategies for Oncology Pharmacists

Pharmacists: 1.00 contact hour (0.1 CEUs)

Released: June 04, 2025

Expiration: December 03, 2025

James Davis
James Davis, PharmD, BCOP
Victoria Nachar
Victoria Nachar, PharmD, BCOP
CME/CE Information

Pretest

Progress
1 2 3
Course Completed
Please answer the questions below.
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1.

Which of the following pairings is correct?

2.

68-Yr-Old Man With Newly Diagnosed CLL



  • A 68-yr-old man was diagnosed CLL with del (17p)/TP53 wild type

  • The patient has a past medical history of hypertension and diabetes

  • The patient needs to initiate therapy because of symptoms and cytopenias

  • He desires a fixed duration, all oral regimen because of his career as a truck driver

In your clinical practice, which of the following would you recommend as the best first-line therapy for this patient?

3.

Patient With PD After Venetoclax + Obinutuzumab and Acalabrutinib



  • 76-yr-old man with CLL who relapsed following venetoclax + obinutuzumab 8 mo after completing fixed-duration therapy is currently receiving acalabrutinib

  • He has tolerated continuous acalabrutinib well, but 3 yr later, he has slowly progressive symptomatic disease

  • His WBC count is 36 x 109/L, hemoglobin is 10.4 g/dL, and platelet count is 80 x 109/L

  • FISH panel shows no del(17p) or TP53 mutation; however, mutation testing reveals a BTK C481 mutation

In your current practice, what would you consider to be the optimal therapy for this patient?

4.

Patient With Relapsed CLL Initiating Acalabrutinib



  • 76-yr-old man with TP53-mutated CLL relapsed following venetoclax + obinutuzumab 8 mo after completing fixed-duration therapy recently initiated acalabrutinib

  • His WBC count is 54 x 109/L, hemoglobin is 10.4 g/dL, and platelet count is 180 x 109/L

  • He has tolerated continuous acalabrutinib well, with the exception of nagging (grade 2) muscle pain that limits his activities of daily living

In your current practice, what would you consider to be the optimal management for this patient’s myalgia?

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