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Navigating Optimal Care for Older Adults With HR+/HER2- Metastatic Breast Cancer: Practical Strategies for Overcoming Clinical Barriers

Clinical Thought

For older adults with HR-positive/HER2-negative metastatic breast cancer, success depends on individualizing therapy based on each patient’s medical needs and goals in care. Practical approaches to geriatric assessment, drug toxicity monitoring, and personalized dosing titration can help us tackle the challenge of translating clinical data into day-to-day decisions for effective, tolerable care.

Released: August 29, 2025

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Provided by Clinical Care Options, LLC In partnership with Smart Patients, Inc.

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Supported by an educational grant from Pfizer Inc.

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Faculty Disclosure

Primary Author

Erika Hamilton, MD: researcher (paid to institution): AbbVie, Acerta, Accutar Biotechnology, ADC Therapeutics, AKESOBIO Australia, Amgen, Aravive, ArQule, Artios, Arvinas, AstraZeneca, AtlasMedx, BeiGene, Black Diamond, Bliss BioPharmaceuticals, Boehringer Ingelheim, Bristol Myers Squibb, Cascadian Therapeutics, Clovis, Compugen, Context Therapeutics, Cullinan, Curis, CytomX, Daiichi Sankyo, Dana-Farber Cancer Institute, Dantari, Deciphera, Duality Biologics, eFFECTOR Therapeutics, Eisai, Ellipses, Elucida Oncology, EMD Serono, Fochon, FujiFilm, G1 Therapeutics, Gilead Sciences, H3 Biomedicine, Harpoon, Hutchinson MediPharma, Immunogen, Immunomedics, Incyte, Infinity, Inspirna, InventisBio, Jacobio, Karyopharm, K-Groub Beta, Kind, Leap, Lilly, Loxo Oncology, Lycera, Mabspace Biosciences, MacroGenics, MedImmune, Mersana, Merus, Millennium, Molecular Templates, Myriad Genetic Laboratories, Novartis, Nucana, Olema, OncoMed, Oncothyreon, ORIC Pharmaceuticals, Orinove, Orum, Pfizer, PharmaMar, Pieris, Pionyr Immunotherapeutics, Plexxikon, Prelude, Profound Bio, Radius Health, Regeneron, Relay Therapeutics, Repertoire Immune Medicine, Rgenix, Roche/Genentech, SeaGen, Sermonix, Shattuck, Silverback, StemCentRx, Stemline, Sutro, Syndax, Syros, Taiho, TapImmune, Tesaro, Tolmar, Torque, Treadwell, Verastem, Zenith Epigenetics, Zymeworks; consultant/advisor (paid to institution): Accutar Biotechnology, Arvinas, AstraZeneca, Circle, Daiichi Sankyo, Entos, Gilead Sciences, IQVIA, Janssen, Jazz, Jefferies, Johnson & Johnson, Lilly, Medical Pharma Services, Mersana, Olema, Pfizer, Roche/Genentech, Shorla, Stemline, Tempus Labs, Theratechnologies, Tubulis, Zentalis.