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CDK46 Inhibition in Breast Cancer

CE / CME

CDK4/6 Inhibition in Breast Cancer: Expert Perspectives on Integrating Guideline Updates and Recent Advances Into Practice

Physicians: maximum of 1.50 AMA PRA Category 1 Credits

Registered Nurses: 1.50 Nursing contact hour

Physician Assistants: maximum of 1.50 hours of AAPA Category 1 CME credits

Pharmacists: 1.50 contact hours (0.15 CEUs)

ABIM MOC: maximum of 1.50 Medical Knowledge MOC points

Released: June 30, 2025

Expiration: December 29, 2025

Pretest

Progress
1 2 3
Course Completed
Please answer the questions below.
1.

Patient Case 1: Woman With Grade 3 ILC and  2 Positive Nodes



  • A 58-yr-old woman who is postmenopausal presents with a 3.5-cm right breast mass with  1 suspicious node

  • Initial breast biopsy reveals ILC, grade 3, with the following biomarkers

    • ER 80%, PgR 30%, HER2- by IHC



  • Fine-needle aspiration of a palpable right axillary lymph node reveals adenocarcinoma of the breast

  • BRCA testing: negative

  • Patient undergoes right breast lumpectomy with SLNB

  • Right lumpectomy specimen reveals a 4-cm ILC with 2/3 positive nodes (T2N1)

  • Oncotype Dx RS 26

  • She completed TC x 4 cycles, followed by adjuvant radiation

  • She returns to the clinic now to discuss continued adjuvant treatment

In addition to extended-duration adjuvant endocrine therapy, what additional systemic therapy would be an appropriate treatment for this patient?

2.

How confident are you in your ability to select CDK4/6i therapy for your patients with mBC based on current guidelines and evidence?

3.

Patient Case 3: Woman on Adjuvant Abemaciclib With Diarrhea



  • 55-yr-old postmenopausal woman with T2N1 high grade invasive HR+/HER2- breast cancer started adjuvant abemaciclib 2 mo ago

  • She calls to report adverse effects including 6-8 episodes per day of diarrhea that are difficult to predict despite taking as-needed antidiarrheal medication

  • She says her weight is stable and that she is eating and drinking without problems

  • She also noted fatigue despite adequate sleep and is having trouble returning to work as a result

  • You ask her to hold abemaciclib until her symptoms are resolving

What additional counseling would you provide for this patient as the most appropriate next step in her treatment once diarrhea has resolved?