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CME

Global Perspectives and Clinical Resources to Guide Treatment Decisions and Management of Adverse Events With BTK Inhibitor Therapy in CLL 

Text Module

Read this expert-guided text module to gain a better understanding of the current clinical evidence and global recommendations for BTK inhibitor treatment of chronic lymphocytic leukemia/small lymphocytic lymphoma along with best practices for adverse event management.

Physicians: Maximum of 1.00 AMA PRA Category 1 Credit

Released: March 13, 2025

Expiration: September 12, 2025

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Provided by Clinical Care Options, LLC

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Supporters

Supported by an educational grant from AstraZeneca.

AstraZeneca

Target Audience

This activity is intended for global hematologists, medical oncologists and other healthcare professionals involved in the treatment of patients with CLL.

Program Learning Goal

The goal of this activity is to improve the knowledge and competence of global learners to apply practice-changing clinical data and expert recommendations to optimize the use of current and emerging therapeutic strategies with BKT inhibitors in the care of their patients with CLL.

Learning Objectives

Upon completion of this activity, participants should be able to: 

  • Evaluate the approved BTK inhibitors considering binding, targeted selectivity, global indications, dosing, safety profile, and efficacy

  • Plan BTK inhibitor–based therapeutic strategies for treatment-naive patients with CLL/SLL taking into consideration global indications, expert recommendations, and recent practice-changing clinical trial results

  • Manage toxicities associated with BTK inhibitor therapy to support adherence, appropriate dosing, and treatment continuation for optimal patient outcomes

Disclosure

Clinical Care Options, LLC (CCO) requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose all financial conflicts of interest (COI) they may have with ineligible companies. All relevant COI are thoroughly vetted and mitigated according to CCO policy. CCO is committed to providing its learners with high-quality CME/CE activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of an ineligible company.

The faculty reported the following relevant financial relationships or relationships to products or devices they have with ineligible companies related to the content of this educational activity:

Primary Author

Stephan Stilgenbauer, MD

Medical Director, Comprehensive Cancer Center Ulm
Head, Early Clinical Trials Unit
Head, Division of CLL
Department of Internal Medicine III
Comprehensive Cancer Center Ulm
University Medical Center Ulm
Ulm, Germany

Stephan Stilgenbauer, MD: consultant/advisor/speaker: AbbVie, Amgen, AstraZeneca, BeiGene, Bristol Myers Squibb, Galapagos, Gilead, GlaxoSmithKline, Hoffmann-La Roche, Janssen, Lilly, Novartis, Sunesis.

The planners and content peer reviewers from Clinical Care Options, LLC do not have any relevant financial relationships to disclose.

Instructions for Credit

Participation in this self-study activity should be completed in approximately 1 hour. To successfully complete this activity and receive credit, participants must follow these steps during the period from March 13, 2025, through September 12, 2025:

  1. Login or Sign Up for an account by clicking at the top of this page.

  2. Read the target audience, learning objectives, and faculty disclosures.

  3. View and study the content in its entirety.

  4. Submit answers to the posttest questions and evaluation questions online.

You must receive a test score of at least 65 and respond to all evaluation questions to receive a certificate. After submitting the evaluation, you may access your online certificate by selecting the certificate link on the confirmation page. Records of all CME/CE activities completed can be found on the "My Certificates" page. There are no costs/fees for this activity.

Format

This program has been made available online.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Disclaimer

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Accreditation

Joint Accreditation Statement

In support of improving patient care, Clinical Care Options, LLC (CCO) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physician Continuing Medical Education

CCO designates this enduring material for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CME Passport

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The CME credits that physicians earn from this activity will be submitted to ACCME's CME Passport, a free, centralized web application where you can create a personalized account to view, track, and generate transcripts of your reported CME credit. Visit www.cmepassport.org to create your account.