CLL Tool
Expert Guidance for the Treatment of CLL

Released: August 20, 2024

Expiration: August 19, 2025

References

Acalabrutinib [prescribing information]. Wilmington, DE: AstraZeneca Pharmaceuticals LP; 2024.

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Burger JA, Tedeschi A, Barr PM, et al. Ibrutinib as initial therapy for patients with chronic lymphocytic leukemia. N Engl J Med. 2015;373:2425-2437.

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Ibrutinib [prescribing information]. South San Francisco, CA: Pharmacyclics LLC; 2024.

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Lisocabtagene maraleucel [prescribing information]. Devens, MA: Bristol-Myers Squibb Company; 2024.

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Pirtobrutinib [prescribing information]. Indianapolis, IN: Lilly USA, LLC; 2024.

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Siddiqi T, Maloney DG, Kenderian SS, et al. Lisocabtagene maraleucel (liso-cel) in R/R CLL/SLL: 24-month median follow-up of TRANSCEND CLL 004. Presented at: American Society of Hematology Annual Meeting 2024; December 7-10, 2024. Abstract 330.

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Stilgenbauer S, Eichhorst B, Schetelig J, et al. Venetoclax in relapsed or refractory chronic lymphocytic leukaemia with 17p deletion: a multicentre, open-label, phase 2 study. Lancet Oncol. 2016;17:768-778.

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Thompson PA, Tam CS, O’Brien SM, et al. Fludarabine, cyclophosphamide, and rituximab treatment achieves long-term disease-free survival in IGHV-mutated chronic lymphocytic leukemia. Blood. 2016;127:303-309.

Venetoclax [prescribing information]. North Chicago, IL: AbbVie Inc; 2022. 

Zanubrutinib [prescribing information]. San Mateo, CA: BeiGene USA, Inc.; 2024.

Access to and use of this Interactive Decision Support Tool titled, “Expert Guidance for the Treatment of CLL” is provided subject to the following terms and conditions. PLEASE READ THESE TERMS CAREFULLY.

This Interactive Decision Support Tool is designed to educate healthcare professionals on making optimal management choices for treating patients with CLL. The information provided is based on expert guidance from Farrukh T. Awan, MD, MS, MBA; Jennifer R. Brown, MD, PhD; Nicole Lamanna, MD; Sameer A. Parikh, MBBS; and Jennifer A. Woyach, MD.

The material published by Clinical Care Options reflects the views of the reviewers or authors of the material, not those of Clinical Care Options, LLC, the accredited provider, or the companies providing educational grants. The materials may discuss uses and dosages for therapeutic products that have not been approved by the FDA. A qualified healthcare professional should be consulted before using any therapeutic product discussed. Readers should verify all information and data before treating patients or using any therapies described in these materials.

Although the information contained in the “Expert Guidance for the Treatment of CLL” Interactive Decision Support Tool has been produced and processed from sources believed to be reliable, no warranty, expressed or implied, is made regarding the accuracy, adequacy, completeness, legality, reliability, or usefulness of any information. This disclaimer applies to both the isolated and aggregate uses of the information. Clinical Care Options provides this information on an as-is basis. This disclaimer applies to all material published by Clinical Care Options including but not limited to medical information or opinions. All warranties of any kind, expressed or implied, including but not limited to the implied warranties of merchantability, fitness for a particular purpose, freedom from contamination by computer viruses, and noninfringement of proprietary rights are disclaimed.

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