Faculty

Neeraj Agarwal, MD, FASCO

Professor of Medicine
Senior Director for Clinical Research, Huntsman Cancer Institute (HCI)
Huntsman Cancer Institute (HCI) Presidential Endowed Chair of Cancer Research
Director, Center of Investigational Therapeutics
Director, Genitourinary Oncology Program
Huntsman Cancer Institute
University of Utah (NCI-CCC)
Salt Lake City, Utah

Karim Fizazi, MD, PhD

Full Professor, University of Paris Saclay
President of GETUG
Head of the Genito-Urinary Group
Department of Cancer Medicine
Gustave Roussy
Villejuif, France

Rana R. McKay, MD, FASCO

Professor of Medicine and Urology
Moores Cancer Center
University of California San Diego
La Jolla, California

Provided by

Provided by Clinical Care Options, LLC

Supporters

Supported by an educational grant from Johnson & Johnson and Pfizer Inc.

Johnson & Johnson

Pfizer, Inc.

Target Audience

This activity is intended for oncologists and other healthcare professionals caring for patients with metastatic castration-resistant prostate cancer.

Program Learning Goal

This activity aims to elevate learners' knowledge and competence in applying PARP inhibitor-based treatment strategies to improve patient outcomes with mCRPC. By deepening their utilization of biomarkers in guiding PARPi selection, aligning clinical practice with recent data and best practices, and managing PARPi-associated adverse events, learners will be better equipped to make informed clinical decisions that enhance patient outcomes and tailor care to individual patient needs.

Learning Objectives

Upon completion of this activity, participants should be able to:

Implement best practices in testing and interpreting results, including DNA damage repair alterations, understanding the application to therapy selection
Describe the medical need and rationale for PARP inhibitors and PARP inhibitor-based combinations in mCRPC, evaluating clinical data
Initiate therapy with PARP inhibitor–based combination regimens for the treatment of patients with prostate cancer, taking into account recent guideline updates, expert recommendations, and recent data, including patient subgroup data
Appropriately mitigate and manage adverse events associated with PARP inhibitor combination regimens to improve quality of life, adherence, and outcomes in patients with prostate cancer

Disclosure

Clinical Care Options, LLC (CCO) requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose all financial conflicts of interest (COI) they may have with ineligible companies. All relevant COI are thoroughly vetted and mitigated according to CCO policy. CCO is committed to providing its learners with high-quality CME/CE activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of an ineligible company.

The faculty reported the following relevant financial relationships or relationships to products or devices they have with ineligible companies related to the content of this educational activity:

Primary Author

Neeraj Agarwal, MD, FASCO, has no relevant financial relationships to disclose.

Karim Fizazi, MD, PhD: consultant/advisor/speaker: Amgen, Arvinas, Astellas, AstraZeneca, Bayer, Clovis, CureVac, Daiichi Sankyo, Janssen, MacroGenics, Merck Sharp & Dohme, Novartis/Advanced Accelerator Applications, Orion, Pfizer, Sanofi.

Rana R. McKay, MD, FASCO: consultant/advisor/speakers: Ambrx, Arcus, Artera, AI, AstraZeneca, Aveo, Bayer, Blue Earth Diagnostic, Boundless Bio, Bristol Myers Squibb, Calithera, Caris, Daiichi Sankyo, Dendreon, Exelixis, Johnson & Johnson, Lilly, Neomorph, Nimbus, Novartis, Oncternal, Pfizer, Precede, Sanofi, SeaGen, Sorrento Therapeutics, Sumitomo Pharma, Telix, Tempus.

The planners and content peer reviewers from Clinical Care Options, LLC do not have any relevant financial relationships to disclose.

Instructions for Credit

Participation in this self-study activity should be completed in approximately 1.5 hours. To successfully complete this activity and receive credit, participants must follow these steps during the period from June 19, 2025, through December 18, 2025:

Login or Sign Up for an account by clicking at the top of this page.
Read the target audience, learning objectives, and faculty disclosures.
View and study the content in its entirety.
Submit answers to the posttest questions and evaluation questions online.

You must receive a test score of at least 65 and respond to all evaluation questions to receive a certificate. After submitting the evaluation, you may access your online certificate by selecting the certificate link on the confirmation page. Records of all CME/CE activities completed can be found on the "My Certificates" page. There are no costs/fees for this activity.

Format

This program has been made available online.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Disclaimer

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Accreditation

Joint Accreditation Statement

In support of improving patient care, Clinical Care Options, LLC (CCO) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physician Continuing Medical Education

CCO designates this enduring material for a maximum of 1.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

American Board of Internal Medicine Maintenance of Certification

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1.5 MOC points in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

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CME Passport

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The CME credits that physicians earn from this activity will be submitted to ACCME's CME Passport, a free, centralized web application where you can create a personalized account to view, track, and generate transcripts of your reported CME credit. Visit www.cmepassport.org to create your account.

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Video