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Phase III CROWN: 5-Yr Update of First-line Lorlatinib vs Crizotinib in Advanced ALK-Positive NSCLC

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This 5-year update from the phase III CROWN trial reports durable PFS benefit and prolonged time to intracranial progression with first-line lorlatinib vs crizotinib in patients with advanced ALK-positive NSCLC.

Released: June 03, 2024

Expiration: June 02, 2025

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Supported by educational grants from AstraZeneca; Daiichi Sankyo, Inc.; and Gilead Sciences, Inc.

AstraZeneca

Daiichi Sankyo, Inc.

Gilead Sciences, Inc.