Faculty

Savitri Krishnamurthy, MD

Professor of Pathology
Department of Anatomical Pathology
The University of Texas MD Anderson Cancer Center
Houston, Texas

Liza Quintana, MD

Breast Pathology and Cytopathology
Director, Breast Pathology Fellowship
Beth Israel Deaconess Medical Center
Harvard Medical School
Boston, Massachusetts

Sara M. Tolaney, MD, MPH

Chief, Division of Breast Oncology
Associate Director, Susan F. Smith Center for Women’s Cancers
Senior Physician, Dana-Farber Cancer Institute
Associate Professor of Medicine
Harvard Medical School
Boston, Massachusetts

Provided by

Provided by Clinical Care Options, LLC

Supporters

Supported by educational grants from AstraZeneca and Daiichi Sankyo, Inc.

AstraZeneca

Daiichi Sankyo, Inc.

Target Audience

This educational activity is intended for pathologists, oncologists, and other laboratory and healthcare professionals involved in the precision care of patients with HER2-low/ultralow metastatic breast cancer.

Program Learning Goal

This activity aims to improve learners' knowledge, confidence, and competence in accurately performing pathological assessment, diagnosing, and providing evidence-based treatment strategies for patients with HER2-low/ultralow metastatic breast cancer.

Learning Objectives

Upon completion of this activity, participants should be able to:

Score HER2 levels via immunohistochemistry (IHC) in routine and complex breast cancer cases in accordance with guidelines and expert opinion
Implement pathological procedures to identify patients with metastatic breast cancer who may benefit from HER2-targeted therapy through optimal assessment of HER2 status, and streamline communication of results
Select novel HER2-targeted therapies for treatment of patients with HER2-low/ultralow metastatic breast cancer based on clinical data, guideline recommendations, and patient-/ disease-related factors

Disclosure

Clinical Care Options, LLC (CCO) requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose all financial conflicts of interest (COI) they may have with ineligible companies. All relevant COI are thoroughly vetted and mitigated according to CCO policy. CCO is committed to providing its learners with high-quality CME/CE activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of an ineligible company.

The faculty reported the following relevant financial relationships or relationships to products or devices they have with ineligible companies related to the content of this educational activity:

Program Director

Savitri Krishnamurthy, MD

Professor of Pathology
Department of Anatomical Pathology
The University of Texas MD Anderson Cancer Center
Houston, Texas

Savitri Krishnamurthy, MD: consultant/advisor/speaker: AstraZeneca, Daiichi Sankyo.

Primary Author

Liza Quintana, MD, has no relevant financial relationships to disclose.

Sara M. Tolaney, MD, MPH: consultant/advisor/speaker: Aadi Bio, Artios, Arvinas, AstraZeneca, Bayer, BeiGene, Bicycle, BioNTech, Blueprint Medicines, Bristol Myers Squibb/SystImmune, Circle, Cullinan, Daiichi Sankyo, eFFECTOR, Eisai, Genentech/Roche, Gilead, Hengrui, Incyte, Jazz, Johnson & Johnson/Ambrx, Launch Therapeutics, Lilly, Menarini/Stemline, Merck, Mersana, Natera, Novartis, Pfizer, Reveal Genomics, Sanofi, Seattle Genetics, Sumitovant, Summit Therapeutics, Tango, Umoja Biopharma, Zentalis, Zuellig, Zymeworks; researcher (paid to institution): AstraZeneca, Bristol Myers Squibb/SystImmune, Cyclacel, Eisai, Exelixis, Genentech/Roche, Gilead, Jazz, Lilly, Menarini/Stemline, Merck, Nanostring, Novartis, OncoPep, Pfizer/Seattle Genetics.

The planners and content peer reviewers from Clinical Care Options, LLC do not have any relevant financial relationships to disclose, except Nicolle Rochino, PharmD, RPh, as noted below.

Nicolle Rochino, PharmD, RPh: employee (relationship has ended): Novo Nordisk.

Instructions for Credit

Participation in this self-study activity should be completed in approximately 1 hour. To successfully complete this activity and receive credit, participants must follow these steps during the period from April 25, 2025, through October 24, 2025:

Login or Sign Up for an account by clicking at the top of this page.
Read the target audience, learning objectives, and faculty disclosures.
View and study the content in its entirety.
Submit answers to the posttest questions and evaluation questions online.

You must receive a test score of at least 65 and respond to all evaluation questions to receive a certificate. After submitting the evaluation, you may access your online certificate by selecting the certificate link on the confirmation page. Records of all CME/CE activities completed can be found on the "My Certificates" page. There are no costs/fees for this activity.

Format

This program has been made available online.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Disclaimer

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Accreditation

Joint Accreditation Statement

In support of improving patient care, Clinical Care Options, LLC (CCO) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physician Continuing Medical Education

CCO designates this enduring material for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

American Board of Pathology Continuing Certification

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1 Lifelong Learning point in the American Board of Pathology’s Continuing Certification Program. It is the CME activity provider’s responsibility to submit learner completion information to ACCME for the purpose of granting ABPath Continuing Certification (formerly Maintenance of Certification or MOC) credit.

For ABPath Lifelong Learning points, your information will be shared with the ABPath through CCO’s Joint Accreditation Program and Activity Reporting System (JAPARS). Please allow 6-8 weeks for your Lifelong Learning points to appear on your ABPath records.

By sharing your Diplomate Board ID # and DOB, you are giving Clinical Care Options, LLC permission to use this information/data to report your participation to these Boards via the Joint Accreditation Program and Activity Reporting System (JA-PARS).

CME Passport

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The CME credits that physicians earn from this activity will be submitted to ACCME's CME Passport, a free, centralized web application where you can create a personalized account to view, track, and generate transcripts of your reported CME credit. Visit www.cmepassport.org to create your account.

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Shining a Light on HER2-Low and HER2-Ultralow Metastatic Breast Cancer: A Pathologist’s Guide to Bridging the Diagnostic Gaps

Video