eCase - Gyn Conferences 2022

Introduction

In the year 2022 alone, several clinical advances on new and emerging treatments, biomarkers, and molecular testing modalities were reported across the various annual meetings, including the Society of Gynecologic Oncology (SGO), American Society of Clinical Oncology (ASCO), European Society for Medical Oncology (ESMO), International Gynecologic Cancer Society (IGCS), and European Society of Gynaecological Oncology (ESGO).

This module is a synopsis of key clinical trial data, landmark clinical trial updates, and new original research presented for ovarian, cervical, and endometrial cancers at the various global meetings and as highlighted by our experts: Elisabeth Diver, MD; Jubilee Brown, MD; Angeles Alvarez Secord, MD, MHSc; David Scott Miller, MD, FACOG, FACS; Alexandra Leary, MD, PhD; Domenica Lorusso, MD, PhD; Susana Banerjee, MBBS, MA, PhD, FRCP; Mansoor Raza Mirza, MD; Ignace Vergote, MD, PhD; and Isabelle Ray-Coquard, MD, PhD.

The key points discussed in this module are illustrated with thumbnails from the accompanying downloadable PowerPoint slideset, which can be found here or downloaded by clicking any of the slide thumbnails alongside the expert commentary.

Clinical Care Options plans to measure the educational impact of this activity. A few questions will be asked twice: once at the beginning of the activity and then once again after the discussion that informs the best choice. Your responses will be aggregated for analysis, and your specific responses will not be shared.

Before continuing with this educational activity, please take a moment to answer the following questions.

If you are a practicing healthcare professional, how many patients with gynecologic cancer do you provide care for in a typical month?

A. 1-4
B. 5-10
C. 11-15
D. 16-20
E. >20
F. Not applicable

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Expert Analyses of Key Clinical Developments and Updates Across Gynecologic Malignancies

Susana Banerjee, MBBS, MA, PhD, FRCP

Jubilee Brown, MD

Elisabeth Diver, MD

Alexandra Leary, MD, PhD

Domenica Lorusso, MD, PhD, Prof

David Scott Miller, MD, FACOG, FACS

Mansoor Raza Mirza, MD

Prof Isabelle Ray-Coquard, MD, PhD

Angeles Alvarez Secord, MD, MHSc

Ignace Vergote, MD, PhD

Activity

Introduction

If you are a practicing healthcare professional, how many patients with gynecologic cancer do you provide care for in a typical month?

You are now considering offering maintenance poly-ADP-ribose polymerase (PARP) inhibitor olaparib plus bevacizumab to maximize her PFS interval. Based on results presented at ESMO 2022 from the PAOLA-1 study, which of the following would you be most likely to mention regarding her potential outcome?