eCase - Hematology 2022: MDS and MPNs

Introduction

In this module, Amer Zeidan, MBBS, MPH, and Srdan Verstovsek, MD, PhD, review key studies in myelodysplastic syndromes (MDS) and myeloproliferative neoplasms (MPNs) presented at the 2022 American Society of Hematology (ASH) Annual Meeting.

Please note that the slide thumbnails in this activity link to brief PowerPoint slidesets that also can be found here, each focused on the specific study or topic of interest. These slidesets also may be downloaded by clicking on any of the thumbnails within the activity.

Clinical Care Options plans to measure the educational impact of this activity. Some questions will be asked twice: once at the beginning of the activity and then once again after the discussion that informs the best choice. Your responses will be aggregated for analysis, and your specific responses will not be shared.

Before continuing with this educational activity, please take a moment to answer the following questions.

For those providing patient care, how many patients with MDS or MPNs do you provide care for in a typical month?

A.
1-4
B.
5-10
C.
11-15
D.
16-20
E.
>20
F.
Not applicable

Which of the following results was reported by Cadenas and colleagues from the phase III Sintra-REV trial, which evaluated lenalidomide compared with placebo for up to 2 years in patients with International Prognostic Scoring System (IPSS) low- or intermediate-1‒risk MDS with del(5q) who were transfusion independent?

A.
Increased median time to transfusion dependence
B.
Increased incidence of conversion to acute myeloid leukemia (AML)
C.
Increased clonal expansion in patients with TP53 mutation
D.
Shorter median overall survival (OS)

Which of the following findings was reported by Zeidan and colleagues in the randomized phase II STIMULUS-MDS1 trial evaluating sabatolimab plus hypomethylating agents (HMAs) vs placebo plus HMAs among patients with intermediate- to very high‒risk MDS who were unsuitable for intensive chemotherapy?

A.
Significant improvement in complete response (CR)
B.
Significant improvement in median progression-free survival (PFS)
C.
Significant improvement in CR and median PFS
D.
No statistical improvement in CR or PFS

A patient with high-risk myelofibrosis (MF) is anemic and has MF symptoms despite ruxolitinib therapy; they are now considering different treatment options. How would you counsel this patient regarding ASH 2022 findings with momelotinib from Week 24 to Week 48 in the phase III MOMENTUM trial, in which this agent was compared with danazol for treating patients with MF who had previously received a JAK inhibitor and were anemic and symptomatic?

A.
Most patients who achieved total symptom score (TSS) response and transfusion independence (TI) maintained these outcomes
B.
Most patients who achieved TSS response but few who achieved TI maintained these outcomes
C.
Most patients who achieved TI but few who achieved TSS response maintained these outcomes
D.
Few patients who achieved TSS response and TI maintained these outcomes

Which of the following is a PI3K inhibitor for which positive symptom and spleen size outcomes were reported at ASH 2022 as an add-on therapy to ruxolitinib for patients with MF and a suboptimal response to ruxolitinib, with a current phase III trial underway in this population?

A.
Navitoclax
B.
Parsaclisib
C.
Pelabresib
D.
Selinexor
E.
Siremadlin

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Key Studies in Myelodysplastic Syndromes and Myeloproliferative Neoplasms: Independent Conference Coverage of ASH 2022

Srdan Verstovsek, MD, PhD

Amer Zeidan, MBBS, MHS

Activity

Introduction

For those providing patient care, how many patients with MDS or MPNs do you provide care for in a typical month?

Which of the following is a PI3K inhibitor for which positive symptom and spleen size outcomes were reported at ASH 2022 as an add-on therapy to ruxolitinib for patients with MF and a suboptimal response to ruxolitinib, with a current phase III trial underway in this population?