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CME

Treating the Whole Patient: Understanding Needs of Patients With HR-Positive/HER2-Negative MBC and Comorbidities

Text Module

This module features expert analysis of the current treatment landscape, current guidelines for the use of CDK4/6 inhibitors, and available real-world data on risk factors and clinical complexities surrounding the management of patients with HR-positive/HER2-negative metastatic breast cancer with preexisting comorbid conditions.

Physicians: Maximum of 0.50 AMA PRA Category 1 Credit

Released: March 07, 2025

Expiration: September 06, 2025

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Provided by Clinical Care Options, LLC., in partnership with Practicing Clinicians Exchange (PCE) and ProCE, LLC.

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Supporters

Supported by an educational grant from Pfizer Inc.

Pfizer Inc.

Partners

Practicing Clinicians Exchange

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ProCE, LLC

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Target Audience

This activity is intended for oncologists and other healthcare professionals involved in caring for patients with mBC.

Program Learning Goal

This activity aims to improve learners' knowledge, competence, and performance in improving the comprehensive care of patients with HR+/HER2- mBC and existing comorbidities.

Learning Objectives

Upon completion of this activity, participants should be able to: 

  • Describe common comorbidities and related factors in patients with HR+/HER2- MBC, including cardiovascular disease, polypharmacy, and poor performance status

  • Select individualized treatment for patients with HR+/HER2- MBC, considering efficacy and safety data (RCT/RWE), treatment guidelines, and health status

  • Implement effective multidisciplinary team processes to mitigate and monitor potential drug–drug interactions in patients with comorbid conditions

  • Plan communication strategies, utilizing shared decision-making to optimize patient–physician trust and understand patient goals when selecting MBC treatment

Disclosure

Clinical Care Options, LLC (CCO) requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose all financial conflicts of interest (COI) they may have with ineligible companies. All relevant COI are thoroughly vetted and mitigated according to CCO policy. CCO is committed to providing its learners with high-quality CME/CE activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of an ineligible company.

The faculty reported the following relevant financial relationships or relationships to products or devices they have with ineligible companies related to the content of this educational activity:

Primary Author

Sara A. Hurvitz, MD, FACP

Professor of Medicine
Smith Family Endowed Chair in Women’s Health
Head, Division of Hematology and Oncology
Department of Medicine, UW Medicine
Senior Vice President, Clinical Research Division Fred Hutchinson Cancer Center
Seattle, Washington

Sara A. Hurvitz, MD, FACP: researcher: Arvinas, AstraZeneca, Boehringer Ingelheim, Celcuity, Dantari, G1 Therapeutics, Genentech/Roche, Gilead, Greenwich LifeSciences, Immunomedics, Jazz/Zymeworks, Lilly, Loxo, Novartis, Orinove, Orum, Pfizer, Puma, Radius, Sanofi, Seagen, Stemline/Menarini; data and safety monitoring board: Atossa.

The planners and content peer reviewers from Clinical Care Options, LLC do not have any relevant financial relationships to disclose.

Instructions for Credit

Participation in this self-study activity should be completed in approximately 0.5 hours. To successfully complete this activity and receive credit, participants must follow these steps during the period from March 07, 2025, through September 06, 2025:

  1. Login or Sign Up for an account by clicking at the top of this page.

  2. Read the target audience, learning objectives, and faculty disclosures.

  3. View and study the content in its entirety.

  4. Submit answers to the posttest questions and evaluation questions online.

You must receive a test score of at least 65 and respond to all evaluation questions to receive a certificate. After submitting the evaluation, you may access your online certificate by selecting the certificate link on the confirmation page. Records of all CME/CE activities completed can be found on the "My Certificates" page. There are no costs/fees for this activity.

Format

This program has been made available online.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Disclaimer

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Accreditation

Joint Accreditation Statement

In support of improving patient care, Clinical Care Options, LLC (CCO) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physician Continuing Medical Education

CCO designates this enduring material for a maximum of 0.5 AMA PRA Category 1 Credits™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CME Passport

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The CME credits that physicians earn from this activity will be submitted to ACCME's CME Passport, a free, centralized web application where you can create a personalized account to view, track, and generate transcripts of your reported CME credit. Visit www.cmepassport.org to create your account.