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A New Revolution in AML Treatment: Can Menin Inhibitors Follow the Path of FLT3 and IDH Inhibitors? 

Text Module

Explore the therapeutic potential of menin inhibitors in NPM1-mutated and KMT2A -rearranged AML through this text module with associated downloadable slides that blends expert insights with the latest data.

Physicians: Maximum of 0.75 AMA PRA Category 1 Credit

Released: September 09, 2025

Expiration: March 08, 2026

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Provided by Clinical Care Options, LLC

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Supporters

Supported by educational grants from Johnson & Johnson, Kura Oncology, Inc. and Syndax Pharmaceuticals, Inc. 

Johnson & Johnson

Kura Oncology, Inc.

Syndax Pharmaceuticals, Inc.

Target Audience

This educational activity is intended for hematologists, medical oncologists, and other healthcare professionals who care for patients with acute myeloid leukemia.

Program Learning Goal

This activity aims to improve learners’ knowledge, confidence, and competence at applying emerging clinical data and expert recommendations to optimally integrate menin inhibitors into treatment pathways for eligible patients with acute myeloid leukemia.

Learning Objectives

Upon completion of this activity, participants should be able to: 

  • Educate patients and colleagues on the mechanisms of action for menin inhibitors and the clinical rationale for inhibiting menin in AML

  • Plan individualized treatments leveraging approved or investigational menin inhibitors for patients with relapsed/refractory AML harboring KMT2A rearrangements or NPM1 mutations based on the latest evidence, expert recommendations, and patient-/disease-specific factors

  • Apply evidence-based strategies to mitigate and manage differentiation syndrome related to menin inhibitors in patients with AML 

Disclosure

Clinical Care Options, LLC (CCO) requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose all financial conflicts of interest (COI) they may have with ineligible companies. All relevant COI are thoroughly vetted and mitigated according to CCO policy. CCO is committed to providing its learners with high-quality CME/CE activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of an ineligible company.

The faculty reported the following relevant financial relationships or relationships to products or devices they have with ineligible companies related to the content of this educational activity:

Primary Author

Eytan M. Stein, MD: consultant/advisor/speaker: Syndax.

Eunice S. Wang, MD: consultant/advisor/speaker: AbbVie, Astellas, Blueprint, Daiichi Sankyo, Dark Blue, Dava Oncology, GSK, Kite, Kura, Novartis, Qiagen, Rigel, Ryvu, Schrödinger , Servier, Stemline, Syndax, Pfizer, Takeda; data and safety monitoring committee: AbbVie.

The planners and content peer reviewers from Clinical Care Options, LLC do not have any relevant financial relationships to disclose.

Instructions for Credit

Participation in this self-study activity should be completed in approximately 0.75 hour. To successfully complete this activity and receive credit, participants must follow these steps during the period from September 09, 2025, through March 08, 2026:

  1. Login or Sign Up for an account by clicking at the top of this page.

  2. Read the target audience, learning objectives, and faculty disclosures.

  3. View and study the content in its entirety.

  4. Submit answers to the posttest questions and evaluation questions online.

You must receive a test score of at least 65 and respond to all evaluation questions to receive a certificate. After submitting the evaluation, you may access your online certificate by selecting the certificate link on the confirmation page. Records of all CME/CE activities completed can be found on the "My Certificates" page. There are no costs/fees for this activity.

Format

This program has been made available online.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Disclaimer

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Accreditation

Joint Accreditation Statement

In support of improving patient care, Clinical Care Options, LLC (CCO) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physician Continuing Medical Education

CCO designates this enduring material for a maximum of 0.75 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

CME Passport

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The CME credits that physicians earn from this activity will be submitted to ACCME's CME Passport, a free, centralized web application where you can create a personalized account to view, track, and generate transcripts of your reported CME credit. Visit www.cmepassport.com to create your account.