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A Focus on Oral SERDs in Patients With HR+/HER2- Breast Cancer: Avoiding Early Discontinuation

Clinical Thought

Read my commentary on strategies to improve and maintain adherence to oral SERD therapy, including management of common drug-related adverse events.  

Physicians: Maximum of 0.25 AMA PRA Category 1 Credit

Released: March 27, 2024

Expiration: March 26, 2025



Marla Lipsyc-Sharf

Marla Lipsyc-Sharf, MD

Health Sciences Clinical Instructor of Medicine
Division of Hematology/Oncology
UCLA David Geffen School of Medicine
Los Angeles, California

Provided by

Provided by Clinical Care Options, LLC, in partnership with Practicing Clinicians Exchange and ProCE, LLC

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This activity is supported by an educational grant from Lilly.



Practicing Clinicians Exchange

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Target Audience

This program is intended for oncologists, and other healthcare professionals who care for patients with breast cancer.

Program Learning Goal

The goal of this program is to improve the knowledge, competence, and performance of learners to optimize clinical benefit by maintaining adherence and persistence with oral SERDs in the treatment of patients with HR+/HER2- breast cancer.

Learning Objectives

Upon completion of this activity, participants should be able to:

  • Employ effective techniques to address factors leading to early discontinuation of oral anticancer therapy for the prescribed duration of treatment in patients with HR+/HER2- breast cancer


Clinical Care Options, LLC (CCO) requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose all financial conflicts of interest (COI) they may have with ineligible companies. All relevant COI are thoroughly vetted and mitigated according to CCO policy. CCO is committed to providing its learners with high-quality CME/CE activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of an ineligible company.

The faculty reported the following relevant financial relationships or relationships to products or devices they have with ineligible companies related to the content of this educational activity:

Primary Author

Marla Lipsyc-Sharf, MD

Health Sciences Clinical Instructor of Medicine
Division of Hematology/Oncology
UCLA David Geffen School of Medicine
Los Angeles, California

Marla Lipsyc-Sharf, MD: consultant/advisor/speaker: Natera; independent contractor: Exact Sciences.

The planners and content peer reviewers from Clinical Care Options, LLC, Practicing Clinicians Exchange, and ProCE, LLC, do not have any relevant financial relationships to disclose.

Instructions for Credit

Participation in this self-study activity should be completed in approximately 0.25 hours. To successfully complete this activity and receive credit, participants must follow these steps during the period from March 27, 2024, through March 26, 2025:

  1. Login or Sign Up for an account by clicking at the top of this page.
  2. Read the target audience, learning objectives, and faculty disclosures.
  3. View and study the content in its entirety.
  4. Submit answers to the posttest questions and evaluation questions online.

You must receive a test score of at least 65 and respond to all evaluation questions to receive a certificate. After submitting the evaluation, you may access your online certificate by selecting the certificate link on the confirmation page. Records of all CME/CE activities completed can be found on the "My Certificates" page. There are no costs/fees for this activity.


This program has been made available online.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.


Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.


Joint Accreditation Statement

In support of improving patient care, Clinical Care Options, LLC (CCO) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physician Continuing Medical Education

CCO designates this enduring material for a maximum of 0.25 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.