Faculty

Joseph W. Franses, MD, PhD

Assistant Professor of Medicine
Section of Hematology-Oncology
University of Chicago
Chicago, Illinois

Neehar Parikh, MD, MS

Associate Professor
Li Ka Shing Research Professor of Hepatology
Clinical Director of Hepatology
Medical Director, Liver Tumor Program
Division of Gastroenterology & Hepatology
University of Michigan
Ann Arbor, Michigan

Mark Yarchoan, MD

Associate Professor
Sidney Kimmel Comprehensive Cancer Center
Johns Hopkins
Baltimore, Maryland

Provided by

Provided by Clinical Care Options, LLC

Supporters

Supported by educational grants from Eisai and Merck Sharp & Dohme LLC.

Eisai

Merck Sharp & Dohme, LLC

Target Audience

This activity has been designed to meet the educational needs of oncologists, interventional radiologists, and other clinicians involved in managing HCC.

Program Learning Goal

The goal of this activity is to improve the knowledge and competence of learners in an effort to optimize treatment for patients with HCC.

Learning Objectives

Upon completion of this activity, participants should be able to:

Analyze and apply recent safety and efficacy data alongside evolving guideline recommendations to optimize the integration of systemic therapies in managing resected/ ablated and intermediate-stage HCC
Design comprehensive, personalized treatment strategies that leverage immunotherapy, targeted agents, and locoregional options for patients across all stages of HCC, guided by the latest clinical evidence and individualized patient factors
Implement collaborative care approaches among oncology and interventional radiology teams to enhance patient-centered management of HCC, including seamless care coordination, proactive adverse event management, tailored dosing strategies, and supportive patient/ caregiver education
Identify and evaluate patient eligibility for enrollment in clinical trials investigating ICI-based therapies, ensuring that trial selection aligns with the patient's clinical profile and has the potential to enhance therapeutic outcomes

Disclosure

Clinical Care Options, LLC (CCO) requires instructors, planners, managers, and other individuals who are in a position to control the content of this activity to disclose all financial conflicts of interest (COI) they may have with ineligible companies. All relevant COI are thoroughly vetted and mitigated according to CCO policy. CCO is committed to providing its learners with high-quality CME/CE activities and related materials that promote improvements or quality in healthcare and not a specific proprietary business interest of an ineligible company.

The faculty reported the following relevant financial relationships or relationships to products or devices they have with ineligible companies related to the content of this educational activity:

Primary Author

Joseph W. Franses, MD, PhD: consultant/advisor/speaker: Eisai, Foundation Medicine, Genentech, Guardant Health; researcher: AbbVie, Alnylam, Genentech, Iterion Therapeutics, Omega Therapeutics.

Neehar Parikh, MD, MS: consultant/advisor/speaker: AstraZeneca, Exact Sciences, Exelixis, Fujifilm Medical, Genentech, Sirtex.

Mark Yarchoan, MD: grant (paid to institution): Bristol Myers Squibb, Genentech; consultant/advisor/speaker: AstraZeneca, Exelixis, Incyte, Lantheus; owner: Adventris.

The planners and content peer reviewers from Clinical Care Options, LLC do not have any relevant financial relationships to disclose.

Instructions for Credit

Participation in this self-study activity should be completed in approximately 1 hour. To successfully complete this activity and receive credit, participants must follow these steps during the period from June 26, 2025, through December 25, 2025:

Login or Sign Up for an account by clicking at the top of this page.
Read the target audience, learning objectives, and faculty disclosures.
View and study the content in its entirety.
Submit answers to the posttest questions and evaluation questions online.

You must receive a test score of at least 65 and respond to all evaluation questions to receive a certificate. After submitting the evaluation, you may access your online certificate by selecting the certificate link on the confirmation page. Records of all CME/CE activities completed can be found on the "My Certificates" page. There are no costs/fees for this activity.

Format

This program has been made available online.

Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. The planners of this activity do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of the planners. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

Disclaimer

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient’s conditions and possible contraindications and/or dangers in use, review of any applicable manufacturer’s product information, and comparison with recommendations of other authorities.

Accreditation

Joint Accreditation Statement

In support of improving patient care, Clinical Care Options, LLC (CCO) is jointly accredited by the Accreditation Council for Continuing Medical Education (ACCME), the Accreditation Council for Pharmacy Education (ACPE), and the American Nurses Credentialing Center (ANCC), to provide continuing education for the healthcare team.

Physician Continuing Medical Education

CCO designates this enduring material for a maximum of 1 AMA PRA Category 1 Credit™. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

American Board of Internal Medicine Maintenance of Certification

Successful completion of this CME activity, which includes participation in the evaluation component, enables the participant to earn up to 1 MOC point in the American Board of Internal Medicine’s (ABIM) Maintenance of Certification (MOC) program. It is the CME activity provider’s responsibility to submit participant completion information to ACCME for the purpose of granting ABIM MOC credit.

For ABIM MOC points, your information will be shared with the ABIM through CCO's Joint Accreditation Program and Activity Reporting System (JAPARS). Please allow 6-8 weeks for your MOC points to appear on your ABIM records.

By sharing your Diplomate Board ID # and DOB, you are giving Clinical Care Options, LLC permission to use this information/data to report your participation to these Boards via the Joint Accreditation Program and Activity Reporting System (JA-PARS).

CME Passport

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The CME credits that physicians earn from this activity will be submitted to ACCME's CME Passport, a free, centralized web application where you can create a personalized account to view, track, and generate transcripts of your reported CME credit. Visit www.cmepassport.org to create your account.

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